SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1,4-DIHYDROPYRIDINE DERIVATIVE

  • Tamanna Narsinghani School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India
  • Love Kumar Soni School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India
  • Shikha Chourey School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India

Abstract

A series of substituted 1,4-dihydopyridine derivatives (SC1-SC10) was synthesized via condensation of acetoacetanilide /4-chloro acetoacetanilide and substituted benzaldehyde in methanol with excess amount of ammonia. The synthesized compounds were characterized using FT-IR, NMR and Mass spectroscopic techniques.The anti-bacterial and anti-fungal activity of title compounds was evaluated utilizing paper disc diffusion method. The anti-bacterial activity was determined by using S. aureus and E.coli as the gram-positive and gram negative strains, while Candida albicans was used to evaluate the anti-fungal activity of synthesized compounds. 1,4-dihydropyridine derivative (SC8) with bromo group at para position of phenyl ring attached to dihydropyridine ring and chloro group linked to para position of carbamoyl phenyl ring was found to be the most active anti-bacterial agent, with its activity observed more on gram negative strain (81.76%) as compared to gram positive strain (75.94%). The most active anti-fungal agent was found to be SC1 (86.85%); 1,4-dihydropyridine derivative with hydroxy group at 2nd position and bromo group at 5th position of phenyl ring attached to dihydropyridine ring while chloro group linked to para position of carbamoyl phenyl ring. This suggests the requirement of electron withdrawing group at 3rd and 5th position of dihydropyridine ring for anti-bacterial and anti-fungal activity.

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Author Biographies

Tamanna Narsinghani, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India
Love Kumar Soni, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India
Shikha Chourey, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore, India

References

1. Swarnalatha G, Prasanthi G, Sirisha N, Chetty CM, 1,4-Dihydropyridines: A Multtifunctional Molecule, Int J Chem Tech Res, 2011, 3, 75-89.
2. Desai B, Sureja D, Naliapara Y, Shah A, Saxena AK, Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3,5-bis-N-(substituted phenyl)carbamoyl1,4-dihydropyridines as potential antitubercular agents, Bioorg Med Chem, 2001, 9, 1993-1998.
3. Sirisha K, Achaiah G, Reddy VM, Facile synthesis and antibacterial, antitubercular, and anticancer activities of novel 1,4-dihydropyridines, Arch Pharm Chem Life Sci, 2010, 343, 342-352.
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How to Cite
Narsinghani, T., Soni, L., & Chourey, S. (2017). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1,4-DIHYDROPYRIDINE DERIVATIVE. Journal of Drug Delivery and Therapeutics, 7(7), 142-135. https://doi.org/10.22270/jddt.v7i7.1615