Designing of New Benzotriazole Analogs using Molecular Docking Studies Against Receptor 1EA1.Pdb & 1IYL.Pdb for Treatment of Fungal Infection

  • Mohammad Rizwan Khan Lakshmi Narain College of Pharamcy (RCP), Indore MP India 453331
  • Love Kumar Soni School of Pharmacy, DAVV, Indore MP India 452012
  • R K Nema Lakshmi Narain College of Pharamcy (RCP), Indore MP India 453331
  • Neelam Balekar IPS Academy College of Pharmacy, Rajendra Nagar, Indore MP India 452012

Abstract

Infectious diseases raise consciousness of our global liability and the aptitude of mankind to prepare medicinally significant molecules during the past century has lead to decrease in the mortality rate from numerous infectious diseases. Benzotriazole derivatives have showed activities like antibacterial, antifungal, antiviral, antiprotozoal and anthelmentic action. These investigations propose the option of emerging a lead compound of benzotriazole having a potential antifungal activity. Molecular docking simulation based virtual screening with ligand library having benzotriazole derivatives have been performed to identify possible lead molecules to inhibit 1EA1.pdb & 1IYL.pdb receptor for treatment of fungal infection. Further the docked conformation of ligand should be perfectly overlayed with the crystal structure of the downloaded protein. This testing is completed successful and the docked confirmation of the fluconazole is perfectly superimposed with reference structure of fluconazole used by the Autodock docking algorithm.

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Author Biographies

Mohammad Rizwan Khan, Lakshmi Narain College of Pharamcy (RCP), Indore MP India 453331

Lakshmi Narain College of Pharamcy (RCP), Indore MP India 453331

Love Kumar Soni, School of Pharmacy, DAVV, Indore MP India 452012

School of Pharmacy, DAVV, Indore MP India 452012

R K Nema, Lakshmi Narain College of Pharamcy (RCP), Indore MP India 453331

Lakshmi Narain College of Pharamcy (RCP), Indore MP India 453331

Neelam Balekar, IPS Academy College of Pharmacy, Rajendra Nagar, Indore MP India 452012

IPS Academy College of Pharmacy, Rajendra Nagar, Indore MP India 452012

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How to Cite
Khan, M., Soni, L., Nema, R., & Balekar, N. (2017). Designing of New Benzotriazole Analogs using Molecular Docking Studies Against Receptor 1EA1.Pdb & 1IYL.Pdb for Treatment of Fungal Infection. Journal of Drug Delivery and Therapeutics, 7(7), 139-141. https://doi.org/10.22270/jddt.v7i7.1614