A STABILITY INDICATING MICELLAR LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF DEFERASIROX IN SOLUBILIZED SYSTEM

  • Hitesh Malvia School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India
  • Ashok Kumar School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India
  • Pratibha Sharma School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India
  • Ritesh Mishra API Research & Development Department, Medilux Laboratories Pvt. Ltd., Plot No. 98-99 Sector-I, Pithampur, Dist. Dhar, 454775, (M.P.), India

Abstract

A simple, isocratic and stability indicating micellar liquid chromatographic (MLC) method containing a surfactant solution above its critical micellar concentration (CMC) was developed and validated for determination of Deferasirox (BTBA) content in active pharmaceutical ingredient and its pharmaceutical formulations. The analysis was performed in on isocratic mode at 400C temperature through Thermo Hypersil ODS 100mm×4.6mm, 3 µm particle size columns. The UV detection wavelength was set at 250 nm in the mobile phase containing 0.1 M Cetyl trimethyl ammonium bromide (CTAB) buffer (pH – 2.5) and 10% 1-butanol. The method was successfully validated following as per the requirements of ICH guidelines. The proposed method was successfully applied as stability indicating method for determination of BTBA under different stressed conditions. The method allows accurate and reliable determination of BTBA for drug stability assay in pharmaceutical investigations.

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Author Biographies

Hitesh Malvia, School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India
School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India
Ashok Kumar, School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India

School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India

Pratibha Sharma, School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India

School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore 452 001 (M.P.), India

Ritesh Mishra, API Research & Development Department, Medilux Laboratories Pvt. Ltd., Plot No. 98-99 Sector-I, Pithampur, Dist. Dhar, 454775, (M.P.), India

API Research & Development Department, Medilux Laboratories Pvt. Ltd., Plot No. 98-99 Sector-I, Pithampur, Dist. Dhar, 454775, (M.P.), India

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How to Cite
Malvia, H., Kumar, A., Sharma, P., & Mishra, R. (2017). A STABILITY INDICATING MICELLAR LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF DEFERASIROX IN SOLUBILIZED SYSTEM. Journal of Drug Delivery and Therapeutics, 7(7), 134-136. https://doi.org/10.22270/jddt.v7i7.1612