DESIGNING OF 2, 5-DISUBSTITUTED-1,3,4-THIADIAZOLE DERIVATIVES FOR THEIR ANTICONVULSANT POTENTIAL
QSAR is the study of quantitative relationships between biological activity and the physicochemical properties of a common parent structure molecule. CS chemoffice software utilized for QSAR of series. The reported IC50 values were converted to negative log IC50 values, which were correlated with various descriptors. Upon stepwise, multiple, and sequential regression analysis of descriptor, the statistically significant QSAR equations were obtained. The correlation between the physicochemical parameters and the biological activity were found using the least squares method. The equations having good correlation coefficient (r2), F-test value, SD values and minimum variance were validated by the cross validation method and IC50 and pIC50 values were calculated using Valstat. 5-Benzenesulphonamido-1,3,4-thiadiazol-2-sulphonamide, was designed as parent structure.
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