DESIGNING OF 2, 5-DISUBSTITUTED-1,3,4-THIADIAZOLE DERIVATIVES FOR THEIR ANTICONVULSANT POTENTIAL

  • Mahavir Chhajed Indore Institute of Pharmacy, Pithampur Road, Opp. IIM, Rau, Indore-453331 (MP) India
  • A K Shrivastava Nandini Nagar Mahavidyalaya College of Pharmacy, Gonda (UP) India
  • Atika Chhajed Institute of Pharmacy, APJ Abdul Kalam University, Arandiya, Indore (MP) India;
  • Vijay Taile Gangwal Chemicals Pvt. Ltd.,706-707 Quantum Tower, Malad (West), Mumbai, (MS) India

Abstract

QSAR is the study of quantitative relationships between biological activity and the physicochemical properties of a common parent structure molecule. CS chemoffice software utilized for QSAR of series. The reported IC50 values were converted to negative log IC50 values, which were correlated with various descriptors. Upon stepwise, multiple, and sequential regression analysis of descriptor, the statistically significant QSAR equations were obtained. The correlation between the physicochemical parameters and the biological activity were found using the least squares method. The equations having good correlation coefficient (r2), F-test value, SD values and minimum variance were validated by the cross validation method and IC50 and pIC50 values were calculated using Valstat. 5-Benzenesulphonamido-1,3,4-thiadiazol-2-sulphonamide, was designed as parent structure.

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Author Biographies

Mahavir Chhajed, Indore Institute of Pharmacy, Pithampur Road, Opp. IIM, Rau, Indore-453331 (MP) India
Indore Institute of Pharmacy, Pithampur Road, Opp. IIM, Rau, Indore-453331 (MP) India
A K Shrivastava, Nandini Nagar Mahavidyalaya College of Pharmacy, Gonda (UP) India
Nandini Nagar Mahavidyalaya College of Pharmacy, Gonda (UP) India
Atika Chhajed, Institute of Pharmacy, APJ Abdul Kalam University, Arandiya, Indore (MP) India;
Institute of Pharmacy, APJ Abdul Kalam University, Arandiya, Indore (MP) India;
Vijay Taile, Gangwal Chemicals Pvt. Ltd.,706-707 Quantum Tower, Malad (West), Mumbai, (MS) India
Gangwal Chemicals Pvt. Ltd.,706-707 Quantum Tower,  Malad (West), Mumbai, (MS) India

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How to Cite
Chhajed, M., Shrivastava, A., Chhajed, A., & Taile, V. (2017). DESIGNING OF 2, 5-DISUBSTITUTED-1,3,4-THIADIAZOLE DERIVATIVES FOR THEIR ANTICONVULSANT POTENTIAL. Journal of Drug Delivery and Therapeutics, 7(7), 118-120. https://doi.org/10.22270/jddt.v7i7.1606