SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW SUBSTITUTED AZETIDINE DERIVATIVES

  • Rajni Shah G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India
  • Deepesh Rathore G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India
  • Farzana Khan G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India
  • Nitin Deshmukh G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India
  • Sujit Pillai G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

Abstract

Four-membered nitrogen heterocycles such as β-lactams and azetidines are useful substrates in organic chemistry for the design and preparation of biologically active compounds. New series of 4(3-Chloro-(Substituted-Phenyl)-4-oxoazetidine1-yl)1-phenylthiosemicaebazide derivative were synthesized by the reaction of Schiff base with 2-Chloro acetyl chloride. Synthesized compounds were evaluated for their Anti- bacterial activity against Gram positive bacteria (Bacillus Subtilis) and gram negative bacteria (Klebsiella pneumonia). In this synthesis 6 derivatives are used named as NM1, NM2, NM3, NM4, NM5 and NM6.Synthesized compounds show significant activity against bacteria strains on agar plate. Their structures were established on the basis of elemental analysis, IR and NMR spectral data. The different substituted azetidine derivatives were synthesized followed by cyclization reaction. The newly synthesized azetidine derivatives were evaluated for their antimicrobial activity. The synthesized compounds NM1 showed effective antimicrobial activity. This clearly indicates that new azetidine derivatives can be effectively synthesized by method mentioned in this study. 

Downloads

Download data is not yet available.

Author Biographies

Rajni Shah, G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India
G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India
Deepesh Rathore, G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

Farzana Khan, G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

Nitin Deshmukh, G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

Sujit Pillai, G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

G.R.Y. Institute Pharmacy, Borawan, Khargone MP, India

References

1. Rao BG, Prasad AVGS, Synthesis And Biological Evaluation Of Novel Azetidine Derivative, IJIRD, 2013, 2, 72-75.
2. Murendra M, Hussain A, synthesis, characterization and biological evaluation of some 5-(substituted amino alkyl)-2-{(1,3-benzothiazole-2-yl)}-thiazolodine-4one Mannich bases as potent antibacterial agents, JAPS, 2013, 3, 135-138.
3. Deshmukh N, Synthesis of Pharmaceutically Important 1,3,4-Thiadiazole Derivatives as Antimicrobials, JC, 2014, 3, 51-53.
4. Patel R, Bhandari A, Synthesis and Antimicrobial Screening of some Azetidine Derivatives AJADD, 2014, 1, 104-109.
Statistics
43 Views | 64 Downloads
How to Cite
Shah, R., Rathore, D., Khan, F., Deshmukh, N., & Pillai, S. (2017). SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW SUBSTITUTED AZETIDINE DERIVATIVES. Journal of Drug Delivery and Therapeutics, 7(7), 113-115. https://doi.org/10.22270/jddt.v7i7.1604