DOCKING POTENTIAL OF SOME N-SUBSTITUTED-DIARYL-PYRAZOLINE ANALOGUES TOWARDS THE COX-2 ENZYME

  • Upendra Bhadoriya IPS Academy College of Pharmacy, Indore (M.P.), India.
  • Dinesh Kumar Jain IPS Academy College of Pharmacy, Indore (M.P.), India.

Abstract

Some N-substituted-diaryl-pyrazoline analogues were investigated insilico for their docking potential towards the Cyclooxygenase (COX)-2 enzyme. The compounds were designed on the basis of rational selection & the PDB entry 1CX2 from RCSB Protein Data Bank was used for mimicking COX-2 binding sites. The Compound (E)-3-(4-(dimethylamino)phenyl)-1-(5-(4-(dimethylamino)phenyl)-3-(4-hydroxyphenyl)-4,5 dihydropyrazol-1-yl)prop-2-en-1-one (E5) was found to possess strong binding potential along with two H-bond. The H-bond with Tyr-355 residue suggests desired COX-2 inhibitory potential of compound E5.

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Author Biographies

Upendra Bhadoriya, IPS Academy College of Pharmacy, Indore (M.P.), India.

IPS Academy College of Pharmacy, Indore (M.P.), India.

Dinesh Kumar Jain, IPS Academy College of Pharmacy, Indore (M.P.), India.

IPS Academy College of Pharmacy, Indore (M.P.), India.

References

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How to Cite
Bhadoriya, U., & Jain, D. (2017). DOCKING POTENTIAL OF SOME N-SUBSTITUTED-DIARYL-PYRAZOLINE ANALOGUES TOWARDS THE COX-2 ENZYME. Journal of Drug Delivery and Therapeutics, 7(7), 107-109. https://doi.org/10.22270/jddt.v7i7.1602