SUSTAINED RELEASE DELIVERY OF REPAGLINIDE BY BIODEGRADABLE MICROSPHERES

  • Gajanan Engla School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore. India
  • L K Soni School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore. India
  • V K Dixit Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar

Abstract

The primary objective of the present study was to prepare repaglinide microspheres for the sustained delivery of the drug for better patient care in the management of diabetics. The biodegradable microspheres of repaglinide is prepare using poly (lactic-co-glycolic acid) (PLGA) by emulsion solvent evaporation technique. The microspheres are prepared with different drug-to-carrier ratios and considering other variables (i.e. solvent, surfactant and stirrer speed) as well. The evaluation of microspheres prepared are perform on the basis of various parameters  like particle size, percentage yield, drug entrapment efficiency, surface morphology, drug-polymer interaction (FT-IR study), in vitro drug release kinetics and stability studies. SEM reveals that microspheres are spherical and has nearly smooth surface morphology. The percentage yield and drug entrapment efficiency is quite well for all the formulations. FT-IR spectra show that there is no chemical interaction between the drug and the polymer. The in vitro release study data shows that the repaglinide release from all the formulations are slow and sustained upto 7days. The various kinetic equations indicate that the in vitro drug release is of zero order release with initial burst from repaglinide microspheres. There is no appreciable difference is observed in the stability study observations.

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Author Biographies

Gajanan Engla, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore. India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore. India

L K Soni, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore. India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore. India

V K Dixit, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar

Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar

References

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How to Cite
Engla, G., Soni, L., & Dixit, V. (2017). SUSTAINED RELEASE DELIVERY OF REPAGLINIDE BY BIODEGRADABLE MICROSPHERES. Journal of Drug Delivery and Therapeutics, 7(7), 77-80. https://doi.org/10.22270/jddt.v7i7.1593