DEVELOPMENT AND EVALUATION OF BUCCAL DOSAGE FORMS OF GARCINIA CAMBOGIA
Medicated jelly formulations are more suitable for pediatric, geriatric and dysphagic patients, which offer rapid dissolution and absorption of drugs thereby early onset of action. The aim of study was to develop and evaluate oral jelly formulation of Garcinia cambogia extract using pectin as the natural gelling agent. The primary objective was formulation of unit moulded jelly containing herbal medicaments and also to optimize the dosage form that will have extra beneficiary for hepatoprotective and weight-loss supplement effect without any side effects. The crude extract or constituents from the plant also exerted hypolipidemic, antidiabetic, anti-inflammatory, anticancer, anthelmintic, anticholinesterase and hepatoprotective activities. All the formulations exhibited good physiochemical properties and found to be stable.
2. Kim MS, Kim JK, Kwon DY, Park R, Anti-adipogenic effects of Garcinia extract on the lipid droplet accumulation and the expression of transcription factor, Biofactors, 2004, 22,193â€“196.
3. Kim KY, Lee HN, Kim YJ & Park T, Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6 J mice fed on a high-fat diet, BBB, 2008,72, 1772â€“1780.
4. Altiner A, Ates A, Gursel FE & Bilal T, Effect of the antiobesity agent Garcinia cambogia extract on serumlipoprotein (a), apolipoproteins a1 and b, and total cholesterol levels in female rats fed atherogenic diet, JAP, 2012, 22, 872â€“877.
5. Rawlins EA, Bentleyâ€™s text book of pharmaceutics, Bailleere Tindall, London, 1995, Edition 18:19-24.
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