FORMULATION AND CHARACTERIZATION OF ALLICIN-AMPHOTERICIN-B LIPOSOMAL GEL FOR THE TREATMENT OF FUNGAL INFECTIONS
Spherical multilammelar vesicles of liposome consisting of lipid egg phosphatidylcholine, soya lecithin and cholesterol were prepared by thin film hydration technique. Further liposomal gel was prepared by egg phosphatidylcholine and cholesterol of molar ratio 7:3 and attained slow drug release with Allicin- Amphotericin B liposomal based gels as compared to the plane gel. Liposomal gel was characterized for drug release kinetics, antifungal activity (disc diffusion assay). Formulation F8 A shows highest drug release. Allicin (Allium sativum Linn.) showed a minimum inhibitory concentration (MIC) at the dose range from 0.195 Âµg/ml to 10 Âµg/ml of broth against all fungal strains (F2B Formulation). These lower concentrations were achievable for fungistatic effect and the reduced adverse effects. The results suggest that liposomal gel of Amphotericin B may be useful in the treatment of Topical Fungal Infections.
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