APPLICATION OF TAGUCHI ORTHOGONAL ARRAY DESIGN FOR OPTIMIZATION OF CHITOSAN NANOPARTICLES OF HYDROPHOBIC CARDIOVASCULAR DRUGS
Nanotechnology based drug delivery system have shown to improve solubility, rate of dissolution and oral bioavailability of poorly water soluble drugs. Present study is aimed to develop Nebivolol loaded chitosan nanoparticles (NB-CS-NPS) for enhancing its oral bioavailability. The NPs optimized by implementation of Taguchi orthogonal array design. The optimized batch (NB-CS-NPS-1) of NPs exhibited average particle size of 91 Â± 45 nm , entrapment efficiency of 70.98% and with zeta potential of + 36.8mV Â± 2mV and stability at 25 Â± 2âˆ˜C/ 60 Â± 5% RH. The in vitro release data studies have shown improved solubility and oral bioavailability of Nebivolol.
2. Nekkanti V, Rueda J, Improved oral bioavailability of valsartan using proliposomes: design, characterization and in vivo pharmacokinetics, Drug Dev Ind Pharm, 2016, 18-27.
3. Kalepu S, Nekkanti V, Insoluble drug delivery strategies: review of recent advances and business prospects, Acta Pharm Sin B, 2015, 442-453.
4. Gulsan T, Gursoy RN, Oner L, Nanocrystal Technology For Oral Delivery of Poorly Water-Soluble Drugs, FABAD J Pharm Sci, 2009, 55-65.
5. Soumya M, Gupta S, Jain R, Mazumder R, Solubility enhancement of poorly water soluble drug by using nano-. suspension technology, Int J Res Dev Pharm Life Sci, 2013, 642-649.
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