APPLICATION OF TAGUCHI ORTHOGONAL ARRAY DESIGN FOR OPTIMIZATION OF CHITOSAN NANOPARTICLES OF HYDROPHOBIC CARDIOVASCULAR DRUGS
Nanotechnology based drug delivery system have shown to improve solubility, rate of dissolution and oral bioavailability of poorly water soluble drugs. Present study is aimed to develop Nebivolol loaded chitosan nanoparticles (NB-CS-NPS) for enhancing its oral bioavailability. The NPs optimized by implementation of Taguchi orthogonal array design. The optimized batch (NB-CS-NPS-1) of NPs exhibited average particle size of 91 Â± 45 nm , entrapment efficiency of 70.98% and with zeta potential of + 36.8mV Â± 2mV and stability at 25 Â± 2âˆ˜C/ 60 Â± 5% RH. The in vitro release data studies have shown improved solubility and oral bioavailability of Nebivolol.
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