FORMULATION AND EVALUATION OF BILAYER TABLET OF METRONIDAZOLE AND DICYCLOMINE HYDROCHLORIDE FOR TREATMENT OF IRRITABLE BOWEL DISEASE
Abstract
The aim of the present study was to prepare bi-layer tablet of Metronidazole and Dicyclomine Hydrochloride for the effective treatment of Irritable Bowel Disease. Metronidazole and Dicyclomine Hydrochloride were formulated as immediate and sustained release layer respectively. The rational for formulation of bi-layer tablet of these two combinations was Metronidazole (immediate release) is strong antibiotic usually applied for antidiarrheal to treat inflammation of the large intestine and Dicyclomine Hydrochloride (Sustained release) is anticholinergic drug primarily used for irritable bowel disease. Bilayer tablet was suitable for maximizing the efficacy of drugs in irritable bowel disease.
Downloads
Download data is not yet available.
References
1. Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P, Jones R, Kumar D, Rubin G, Trudgill N, Whorwell P, Guidelines on the irritable bowel syndrome: mechanisms and practical management, Gut, 2008, 1770-1798.
2. Admassu A, Akseli I, Sprockel O, Kottala N, Cuitino AM, Review of bilayer tablet technology, Int J Pharm, 2013, 549-558.
3. Kumar ES, Ishaq BM, Muneer S, Shreedhar V, Ahed HA, Prakash KV, Simple quantitative method development and validation of capecitabine in pure form and pharmaceutical dosage form by uv-spectroscopy, Indo Am J Pharm Sci 2014, 1-10.
4. Shiyani B, Gattani S, Surana S, Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques, AAPS Pharma Sci Tech, 2008, 818-827.
2. Admassu A, Akseli I, Sprockel O, Kottala N, Cuitino AM, Review of bilayer tablet technology, Int J Pharm, 2013, 549-558.
3. Kumar ES, Ishaq BM, Muneer S, Shreedhar V, Ahed HA, Prakash KV, Simple quantitative method development and validation of capecitabine in pure form and pharmaceutical dosage form by uv-spectroscopy, Indo Am J Pharm Sci 2014, 1-10.
4. Shiyani B, Gattani S, Surana S, Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques, AAPS Pharma Sci Tech, 2008, 818-827.
Statistics
222 Views | 166 Downloads
How to Cite
1.
Sharma A, Sharma P, Darwhekar G. FORMULATION AND EVALUATION OF BILAYER TABLET OF METRONIDAZOLE AND DICYCLOMINE HYDROCHLORIDE FOR TREATMENT OF IRRITABLE BOWEL DISEASE. JDDT [Internet]. 21Dec.2017 [cited 23Jan.2021];7(7):56-8. Available from: http://jddtonline.info/index.php/jddt/article/view/1586
Section
Research
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.