FORMULATION AND EVALUATION OF BILAYER TABLET OF METRONIDAZOLE AND DICYCLOMINE HYDROCHLORIDE FOR TREATMENT OF IRRITABLE BOWEL DISEASE

  • Avinash Sharma Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India
  • Pravin Kumar Sharma Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India
  • Gajanan Darwhekar Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

Abstract

The aim of the present study was to prepare bi-layer tablet of Metronidazole and Dicyclomine Hydrochloride for the effective treatment of Irritable Bowel Disease. Metronidazole and Dicyclomine Hydrochloride were formulated as immediate and sustained release layer respectively. The rational for formulation of bi-layer tablet of these two combinations was Metronidazole (immediate release) is strong antibiotic usually applied for antidiarrheal to treat inflammation of the large intestine and Dicyclomine Hydrochloride (Sustained release) is anticholinergic drug primarily used for irritable bowel disease. Bilayer tablet was suitable for maximizing the efficacy of drugs in irritable bowel disease.

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Author Biographies

Avinash Sharma, Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

Pravin Kumar Sharma, Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

Gajanan Darwhekar, Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India

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How to Cite
Sharma, A., Sharma, P., & Darwhekar, G. (2017). FORMULATION AND EVALUATION OF BILAYER TABLET OF METRONIDAZOLE AND DICYCLOMINE HYDROCHLORIDE FOR TREATMENT OF IRRITABLE BOWEL DISEASE. Journal of Drug Delivery and Therapeutics, 7(7), 56-58. https://doi.org/10.22270/jddt.v7i7.1586