FORMULATION AND EVALUATION OF BILAYER TABLET OF METRONIDAZOLE AND DICYCLOMINE HYDROCHLORIDE FOR TREATMENT OF IRRITABLE BOWEL DISEASE
The aim of the present study was to prepare bi-layer tablet of Metronidazole and Dicyclomine Hydrochloride for the effective treatment of Irritable Bowel Disease. Metronidazole and Dicyclomine Hydrochloride were formulated as immediate and sustained release layer respectively. The rational for formulation of bi-layer tablet of these two combinations was Metronidazole (immediate release) is strong antibiotic usually applied for antidiarrheal to treat inflammation of the large intestine and Dicyclomine Hydrochloride (Sustained release) is anticholinergic drug primarily used for irritable bowel disease. Bilayer tablet was suitable for maximizing the efficacy of drugs in irritable bowel disease.
2. Admassu A, Akseli I, Sprockel O, Kottala N, Cuitino AM, Review of bilayer tablet technology, Int J Pharm, 2013, 549-558.
3. Kumar ES, Ishaq BM, Muneer S, Shreedhar V, Ahed HA, Prakash KV, Simple quantitative method development and validation of capecitabine in pure form and pharmaceutical dosage form by uv-spectroscopy, Indo Am J Pharm Sci 2014, 1-10.
4. Shiyani B, Gattani S, Surana S, Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques, AAPS Pharma Sci Tech, 2008, 818-827.
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