DIALLYLDISULFIDE CONTAINING POLYMERIC NANOPARTICLES FOR SITE-SPECIFIC DELIVERY IN COLON CANCER
Effective delivery of drugs to colon is a challenge, as the drug needs to be protected from gastrointestinal environment and should be released intact in colon.Â Present study is aimed to develop a site-specific nanoparticulate formulation containing herbal anti-cancer agent in treatment of colon cancer. The Diallyl disulfide nanoparticles (DADS-NPs) were prepared by nanoprecipetation method and optimized formulation was selected using Box-Behnken design (BBD). The particle size of NPs was found to be 108 nm. The encapsulation efficiency was found to be 77.24%. and in-vitro release data has revealed controlled and prolonged drug release upto 72h.
2. Udompornmongkol P, Chiang B, Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications, J Biomater Appl, 2015, 537-546.
3. Talluri SV, Kuppusamy G, Karri VVSR, Yamjala K, Multiple biological actions of curcumin in the management of diabetic foot ulcer complications: a systematic review, Artif Cells Nanomed Biotechnol, 2017, 474-488.
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