DIALLYLDISULFIDE CONTAINING POLYMERIC NANOPARTICLES FOR SITE-SPECIFIC DELIVERY IN COLON CANCER

  • Apeksha Saraf School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India
  • Nidhi Dubey School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India

Abstract

Effective delivery of drugs to colon is a challenge, as the drug needs to be protected from gastrointestinal environment and should be released intact in colon.  Present study is aimed to develop a site-specific nanoparticulate formulation containing herbal anti-cancer agent in treatment of colon cancer. The Diallyl disulfide nanoparticles (DADS-NPs) were prepared by nanoprecipetation method and optimized formulation was selected using Box-Behnken design (BBD). The particle size of NPs was found to be 108 nm. The encapsulation efficiency was found to be 77.24%. and in-vitro release data has revealed controlled and prolonged drug release upto 72h.

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Author Biographies

Apeksha Saraf, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India

Nidhi Dubey, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P.), India

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3. Talluri SV, Kuppusamy G, Karri VVSR, Yamjala K, Multiple biological actions of curcumin in the management of diabetic foot ulcer complications: a systematic review, Artif Cells Nanomed Biotechnol, 2017, 474-488.
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How to Cite
Saraf, A., & Dubey, N. (2017). DIALLYLDISULFIDE CONTAINING POLYMERIC NANOPARTICLES FOR SITE-SPECIFIC DELIVERY IN COLON CANCER. Journal of Drug Delivery and Therapeutics, 7(7), 50-51. https://doi.org/10.22270/jddt.v7i7.1584