LIQUISOLID TECHNIQUE AS A PROMISING TOOL TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUG VALSARTAN

  • Madhavi Kasturi Research Scholar, Department of Pharmaceutics, Smriti Collge of Pharmaceutical Education, Indore– 452010
  • Neelesh Malviya Research Scholar, Department of Pharmaceutics, Smriti Collge of Pharmaceutical Education, Indore– 452010

Abstract

“Liquisolid Technique†considered as new technique to enhance solubility and dissolution rate of poorly water soluble drugs. These formulations are prepared by mixing drug in liquid state (solution, suspension or emulsion using non-volatile solvent) with carrier and coating material to form dry, free-flowing, readily compressible powder. In the current research work liquisolid technique is employed to enhance solubility and dissolution of antihypertensive drug Valsartan, which is poorly water soluble (0.021mg/ml) possessing very low bioavailability of 23%. Liquisolid formulation VLS9, containing Tween 80 (non-volatile solvent), Avicel PH102 (carrier) and Aerosil 200 (coating material) showed better flow properties and high in-vitro dissolution profile.

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Author Biographies

Madhavi Kasturi, Research Scholar, Department of Pharmaceutics, Smriti Collge of Pharmaceutical Education, Indore– 452010

Research Scholar, Department of Pharmaceutics, Smriti Collge of Pharmaceutical Education, Indore– 452010

Neelesh Malviya, Research Scholar, Department of Pharmaceutics, Smriti Collge of Pharmaceutical Education, Indore– 452010

Research Scholar, Department of Pharmaceutics, Smriti Collge of Pharmaceutical Education, Indore– 452010

References

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2. Leidig M, Bambauer R, Kirchertz EJ, Szabã T, Handrock R, Leinung D, Efficacy, safety and tolerability of valsartan 80 mg compared to irbesartan 150 mg in hypertensive patients on long-term hemodialysis (VALID study, Clin Nephrol, 2008, 425-432.
3. Gubbi S, Ravindra J, Formulation and characterisation of atorvastatin calcium liquisolid compacts, Asian J Pharm, 2010, 50-60.
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How to Cite
Kasturi, M., & Malviya, N. (2017). LIQUISOLID TECHNIQUE AS A PROMISING TOOL TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUG VALSARTAN. Journal of Drug Delivery and Therapeutics, 7(7), 46-49. https://doi.org/10.22270/jddt.v7i7.1583