LIQUISOLID TECHNIQUE AS A PROMISING TOOL TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUG VALSARTAN
â€œLiquisolid Techniqueâ€ considered as new technique to enhance solubility and dissolution rate of poorly water soluble drugs. These formulations are prepared by mixing drug in liquid state (solution, suspension or emulsion using non-volatile solvent) with carrier and coating material to form dry, free-flowing, readily compressible powder. In the current research work liquisolid technique is employed to enhance solubility and dissolution of antihypertensive drug Valsartan, which is poorly water soluble (0.021mg/ml) possessing very low bioavailability of 23%. Liquisolid formulation VLS9, containing Tween 80 (non-volatile solvent), Avicel PH102 (carrier) and Aerosil 200 (coating material) showed better flow properties and high in-vitro dissolution profile.
2. Leidig M, Bambauer R, Kirchertz EJ, SzabÃ£ T, Handrock R, Leinung D, Efficacy, safety and tolerability of valsartan 80 mg compared to irbesartan 150 mg in hypertensive patients on long-term hemodialysis (VALID study, Clin Nephrol, 2008, 425-432.
3. Gubbi S, Ravindra J, Formulation and characterisation of atorvastatin calcium liquisolid compacts, Asian J Pharm, 2010, 50-60.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).