SOLUBILITY ENHANCEMENT OF EFAVIRENZ (BCS CLASS II DRUG) BY CYCLODEXTRIN INCLUSION COMPLEX TECHNIQUE
The solubility of BCS class II drugs can be enhanced using inclusion complex techniques. Cyclodextrin (CD) and its derivatives are promising carrier for the enhancement of aqueous solubility of drugs. The use of the Kneading technique to obtain solid inclusion system permitted the formation of a uniform, substantially non-crystalline particle, which increased the solubility and stability of Efavirenz (EFV). The present work shows the enhancement of aqueous solubility of BCS class II drug i.e. EFV by making inclusion complex with Î²-CD. The aqueous solubility of EFV is calculated to be 5Â± 0.003 Âµg/ml which was increased up to 288.9Â±0.005 Âµg/ml when complexed with Î²-CD in ratio of 1:1 and 318.5Â± 0.03 Âµg/ml in ratio of 1:2. This shows that, the inclusion complex technique is a promising way to enhance aqueous solubility.
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