SOLUBILITY ENHANCEMENT OF EFAVIRENZ (BCS CLASS II DRUG) BY CYCLODEXTRIN INCLUSION COMPLEX TECHNIQUE

  • Mrittunjay Vyas Acropolis Institute of Pharmaceutical Education and Research, Indore
  • Harsha Jain Acropolis Institute of Pharmaceutical Education and Research, Indore
  • Ravi Sharma Acropolis Institute of Pharmaceutical Education and Research, Indore
  • G N Darwhekar Acropolis Institute of Pharmaceutical Education and Research, Indore

Abstract

The solubility of BCS class II drugs can be enhanced using inclusion complex techniques. Cyclodextrin (CD) and its derivatives are promising carrier for the enhancement of aqueous solubility of drugs. The use of the Kneading technique to obtain solid inclusion system permitted the formation of a uniform, substantially non-crystalline particle, which increased the solubility and stability of Efavirenz (EFV). The present work shows the enhancement of aqueous solubility of BCS class II drug i.e. EFV by making inclusion complex with β-CD. The aqueous solubility of EFV is calculated to be 5± 0.003 µg/ml which was increased up to 288.9±0.005 µg/ml when complexed with β-CD in ratio of 1:1 and 318.5± 0.03 µg/ml in ratio of 1:2. This shows that, the inclusion complex technique is a promising way to enhance aqueous solubility.

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Author Biographies

Mrittunjay Vyas, Acropolis Institute of Pharmaceutical Education and Research, Indore

Acropolis Institute of Pharmaceutical Education and Research, Indore

Harsha Jain, Acropolis Institute of Pharmaceutical Education and Research, Indore

Acropolis Institute of Pharmaceutical Education and Research, Indore

Ravi Sharma, Acropolis Institute of Pharmaceutical Education and Research, Indore

Acropolis Institute of Pharmaceutical Education and Research, Indore

G N Darwhekar, Acropolis Institute of Pharmaceutical Education and Research, Indore

Acropolis Institute of Pharmaceutical Education and Research, Indore

References

1. Maurin MB, Rowe SM, Blom K, Pierce ME, Kinetics and mechanism of hydrolysis of efavirenz, Pharm Res, 2002, 517-521.
2. Srivalli KM, Mishra B, Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances, AAPS Pharm Sci Tech, 2016, 272-283.
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How to Cite
Vyas, M., Jain, H., Sharma, R., & Darwhekar, G. (2017). SOLUBILITY ENHANCEMENT OF EFAVIRENZ (BCS CLASS II DRUG) BY CYCLODEXTRIN INCLUSION COMPLEX TECHNIQUE. Journal of Drug Delivery and Therapeutics, 7(7), 41-43. https://doi.org/10.22270/jddt.v7i7.1581