FORMULATION OF PACLITAXEL LOADED NANOSTRUCTURED LIPID CARRIERS TO STUDY THE EFFECT OF CONCENTRATION OF LIQUID LIPIDS ON DRUG RELEASE

  • Arti Majumdar Smriti College of Pharmaceutical Education, Indore, India
  • Nidhi Dubey School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India

Abstract

In the present study, stearic acid (SA) nanostuctured lipid carriers (NLC) with different proportions of oleic acid (OA) were successfully prepared by solvent diffusion method in an aqueous system. OA was taken in the concentration of 10%, 20%, 30%, 40% and 50%. Prepared NLCs were evaluated for various parameters like drug entrapment efficiency, drug loading and in vitro release. A biphasic drug release pattern was observed; initially a fast release was obtained followed by sustained release at a constant rate. The drug release from nanoparticles was found to be significantly influenced by OA content.

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Author Biographies

Arti Majumdar, Smriti College of Pharmaceutical Education, Indore, India

Smriti College of Pharmaceutical Education, Indore, India

Nidhi Dubey, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India

References

1. Korting HC &Schäfer-Korting M, Carriers in the topical treatment of skin disease. Drug delivSchäfer-Korting M ed: Handbook of Experimental Pharmacology, 2010, 435-468.
2. Parajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar Ram C, Potential application of dendrimers in drug delivery: A concise review and update, Journal of Drug Delivery & Therapeutics. 2016; 6(2):62-70
3. Miryala V, Kurakula M, Self-nano emulsifying drug delivery systems (SNEDDS) for oral delivery of atorvastatin–formulation and bioavailability studies, Journal of Drug Delivery & Therapeutics, 2013; 3(3):131-142.
4. Sanghai B, Aggarwal G, HariKumar SL, Solid self microemulsifying drug deliviry system: a review, Journal of Drug Delivery and Therapeutics. 2013; 3 (3):168-174
5. Radtke M, Souto EB, Muller RH, Nano-Structured Lipid Carriers: a novel generation of solid lipid drug carriers, Pharm Technol Eur, 2005, 17, 45–50.
6. HuFQ, JiangSP, DuYZ, Preparation and characterization of stearic acid nano structured lipid carriers by solvent diffusion method in anaqueous system, Colloids Surf B Biointerfaces, 2005, 45, 167–73.
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How to Cite
Majumdar, A., & Dubey, N. (2017). FORMULATION OF PACLITAXEL LOADED NANOSTRUCTURED LIPID CARRIERS TO STUDY THE EFFECT OF CONCENTRATION OF LIQUID LIPIDS ON DRUG RELEASE. Journal of Drug Delivery and Therapeutics, 7(7), 26-28. https://doi.org/10.22270/jddt.v7i7.1576