FORMULATION OF PACLITAXEL LOADED NANOSTRUCTURED LIPID CARRIERS TO STUDY THE EFFECT OF CONCENTRATION OF LIQUID LIPIDS ON DRUG RELEASE
In the present study, stearic acid (SA) nanostuctured lipid carriers (NLC) with different proportions of oleic acid (OA) were successfully prepared by solvent diffusion method in an aqueous system. OA was taken in the concentration of 10%, 20%, 30%, 40% and 50%. Prepared NLCs were evaluated for various parameters like drug entrapment efficiency, drug loading and in vitro release. A biphasic drug release pattern was observed; initially a fast release was obtained followed by sustained release at a constant rate. The drug release from nanoparticles was found to be significantly influenced by OA content.
2. Parajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar Ram C, Potential application of dendrimers in drug delivery: A concise review and update, Journal of Drug Delivery & Therapeutics. 2016; 6(2):62-70
3. Miryala V, Kurakula M, Self-nano emulsifying drug delivery systems (SNEDDS) for oral delivery of atorvastatinâ€“formulation and bioavailability studies, Journal of Drug Delivery & Therapeutics, 2013; 3(3):131-142.
4. Sanghai B, Aggarwal G, HariKumar SL, Solid self microemulsifying drug deliviry system: a review, Journal of Drug Delivery and Therapeutics. 2013; 3 (3):168-174
5. Radtke M, Souto EB, Muller RH, Nano-Structured Lipid Carriers: a novel generation of solid lipid drug carriers, Pharm Technol Eur, 2005, 17, 45â€“50.
6. HuFQ, JiangSP, DuYZ, Preparation and characterization of stearic acid nano structured lipid carriers by solvent diffusion method in anaqueous system, Colloids Surf B Biointerfaces, 2005, 45, 167â€“73.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).