FORMULATION OF PACLITAXEL LOADED NANOSTRUCTURED LIPID CARRIERS TO STUDY THE EFFECT OF CONCENTRATION OF LIQUID LIPIDS ON DRUG RELEASE
In the present study, stearic acid (SA) nanostuctured lipid carriers (NLC) with different proportions of oleic acid (OA) were successfully prepared by solvent diffusion method in an aqueous system. OA was taken in the concentration of 10%, 20%, 30%, 40% and 50%. Prepared NLCs were evaluated for various parameters like drug entrapment efficiency, drug loading and in vitro release. A biphasic drug release pattern was observed; initially a fast release was obtained followed by sustained release at a constant rate. The drug release from nanoparticles was found to be significantly influenced by OA content.
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