AN APPROACH FOR DESIGNING OF TRANSDERMAL PATCHES FOR PROPHYLAXIS AND TREATMENT OF HIV/AIDS
Transdermal drug delivery is an alternative route for systemic drug delivery system, which minimizes the absorption of drugs and increases the bioavailability through systemic circulation. Currently available anti-HIV drugs bear some significant drawbacks, such as relatively short half life, low bioavailability, poor permeability and undesirable side effects. The purpose of this work is to formulate and evaluate transdermal drug delivery system of anti-HIV drug using various polymers such as HPMC, PVP and ethyl cellulose by solvent evaporation technique for improvement of bioavailability of drug and reducing toxic effects. By this mean we can achieve dosage form with reduce dosing frequency,Â increase the bioavailability, decrease the degradation and metabolism in the gastrointestinal tract, improve the CNS penetration and inhibit the CNS efflux and deliver them to the target cells effectively with minimal side effects. This paper provides details of preformulation study, drug selection criteria, formulation strategies, evaluation perspective, Stability approaches for sustain drug release kinetics.
2. Sosnik A, Chiappetta DA, Carcaboso AM, Drug delivery systems in HIV pharmacotherapy: What has been done and the challenges standing ahead, J Control Release, 2009, 138, (1), 2-15.
3. Frezzini C, Leao JC, Porter SJ, Current trends of HIV disease of the mouth, J Oral Pathol Med, 2005, 34,513-531.
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