PREPARATION AND EVALUATION OF IRBESARTAN-CYCLODEXTRIN INCLUSION COMPLEXES

  • Rajashree Hirlekar Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai-400074
  • V J Kadam Bharati Vidyapeeth’s College of Pharmacy, Navi Mumbai-400614

Abstract

In the present work effect of methyl-β-cyclodextrin (MβCD) on physical properties and dissolution rate of Irbesartan (IRB) was studied.Based on AL-type ofphase solubility diagram obtained, solid binary systems of the drug with MβCD were prepared in 1:1 molar ratio by various methods. Complexes were characterized using Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that IRB can form inclusion complex with MβCD. The dissolution profiles of inclusion complexes were compared with those of IRB alone and the physical mixture. The dissolution rate of IRB was increased remarkably by MβCD inclusion complexation.

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Author Biographies

Rajashree Hirlekar, Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai-400074

Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai-400074

V J Kadam, Bharati Vidyapeeth’s College of Pharmacy, Navi Mumbai-400614

Bharati Vidyapeeth’s College of Pharmacy, Navi Mumbai-400614

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How to Cite
Hirlekar, R., & Kadam, V. (2017). PREPARATION AND EVALUATION OF IRBESARTAN-CYCLODEXTRIN INCLUSION COMPLEXES. Journal of Drug Delivery and Therapeutics, 7(7), 18-20. https://doi.org/10.22270/jddt.v7i7.1573