FORMULATION AND EVALUATION OF IVERMECTIN SOLID DISPERSION
This study was aimed to formulate and evaluate solid dispersion containing ivermectin to improve solubility. Ivermectin is BCS (Biopharmaceutical classification system) class-II drug, which has high permeability and low water solubility (0.005mg/ml) which is responsible for its poor dissolution rate and ultimately leads to variable absorption. Solid dispersion with Gelucire (44/14) has the ability to improve dissolution of poor water soluble drugs. So, solid dispersion ivermectin with Gelucire 44/14 was prepared to enhance the solubility and was further evaluated for different parameters such as assay, wettability, DSC, FT-IR, dissolution study.
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