FORMULATION AND EVALUATION OF IVERMECTIN SOLID DISPERSION
This study was aimed to formulate and evaluate solid dispersion containing ivermectin to improve solubility. Ivermectin is BCS (Biopharmaceutical classification system) class-II drug, which has high permeability and low water solubility (0.005mg/ml) which is responsible for its poor dissolution rate and ultimately leads to variable absorption. Solid dispersion with Gelucire (44/14) has the ability to improve dissolution of poor water soluble drugs. So, solid dispersion ivermectin with Gelucire 44/14 was prepared to enhance the solubility and was further evaluated for different parameters such as assay, wettability, DSC, FT-IR, dissolution study.
2. Dourmishev AL, Dourmishev LA, Schwartz RA, Ivermectin: Pharmacology and application in dermatology, J Dermatol, 2005, 44, 981â€“988.
3. Dalvi P, Gerange A. Ingale P, Solid dispersion: strategy to enhance solubility. Journal of Drug Delivery and Therapeutics, 2015; 5(2):20-28. doi:10.22270/jddt.v5i2.1060
4. Abbas IM, Mahmoud ED, Formulation of immediate release pellets containing famotidine solid dispersions, Saudi Pharm J, 2014, 22, 149â€“156.
5. Fox L, Anne M, Ivermectin: uses and impact 20 years on; Curr Opin Infect Dis, 2006, 19, 588-593.
6. Gupta MM, Patel MG, Patel NS, Kedawat M, Enhancement of dissolution rate of ibuprofen by preparing solid dispersion using different methods, IJPPS, 2011, 3, 204-206.
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