FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLETABLET OF CIPROFLOXACIN WITH ION EXCHANGE RESIN

  • Vishwas Pathak IPS Academy, College of Pharmacy (Indore, MP), India
  • Govinda Bhatt Modern Institute of Pharmaceutical Sciences (Indore, MP), India
  • Sapna Malviya Modern Institute of Pharmaceutical Sciences (Indore, MP), India
  • Anil Kharia Modern Institute of Pharmaceutical Sciences (Indore, MP), India

Abstract

Bitter taste is one of the important formulation problems that are encountered with many drugs, like Ciprofloxacin. In modern times, the most improved & easy technique is to formulate tasteless complexes of ciprofloxacin with ion exchange resin (Indion 234). After acid activation and swelling in water, resin & ciprofloxacin (proper ratio) was stirred for definite time & unbound drug in filtrate was estimated spectrophotometrically and drug-loading efficiency was calculated. The molecular properties of drug complexes by FT-IR study confirm the complexation of ciprofloxacin with Indion 234. The influence of superdisintegrants, crospovidone and sodium starch glycolate on disintegration time, wetting time and water absorption ratio was studied.

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Author Biographies

Vishwas Pathak, IPS Academy, College of Pharmacy (Indore, MP), India

IPS Academy, College of Pharmacy (Indore, MP), India

Govinda Bhatt, Modern Institute of Pharmaceutical Sciences (Indore, MP), India

Modern Institute of Pharmaceutical Sciences (Indore, MP), India

Sapna Malviya, Modern Institute of Pharmaceutical Sciences (Indore, MP), India

Modern Institute of Pharmaceutical Sciences (Indore, MP), India

Anil Kharia, Modern Institute of Pharmaceutical Sciences (Indore, MP), India
Modern Institute of Pharmaceutical Sciences (Indore, MP), India

References

1. Vummaneni V, Taste Masking Technologies: An Overview and Recent Updates, Int J Res Pharm Biomed Sci, 2012, 3, 510-518.
2. Mahore G J, Wadher JK, Ion Exchange Resins: Pharmaceutical Applications and Recent Advancement, IJPSRR, 2010, 1, 8-13.
3. Harish G, Bhargavi C, Effect of different disintegrants on Ciprofloxac in Conventional tablets, IJRPB, 2013, 1, 281-287.
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How to Cite
Pathak, V., Bhatt, G., Malviya, S., & Kharia, A. (2017). FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLETABLET OF CIPROFLOXACIN WITH ION EXCHANGE RESIN. Journal of Drug Delivery and Therapeutics, 7(7), 8-11. https://doi.org/10.22270/jddt.v7i7.1570