FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISPERSIBLETABLET OF CIPROFLOXACIN WITH ION EXCHANGE RESIN
Bitter taste is one of the important formulation problems that are encountered with many drugs, like Ciprofloxacin. In modern times, the most improved & easy technique is to formulate tasteless complexes of ciprofloxacin with ion exchange resin (Indion 234). After acid activation and swelling in water, resin & ciprofloxacin (proper ratio) was stirred for definite time & unbound drug in filtrate was estimated spectrophotometrically and drug-loading efficiency was calculated. The molecular properties of drug complexes by FT-IR study confirm the complexation of ciprofloxacin with Indion 234. The influence of superdisintegrants, crospovidone and sodium starch glycolate on disintegration time, wetting time and water absorption ratio was studied.
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