FORMULATION AND EVALUATION OF TABLETS CONTAINING ARTEMETHER MICROSPHERES AND LUMEFANTRINE
This study was aimed to fabricate and evaluate a combination of Artemether and Lumefantrine as tablets and to make Artemether in sustained form so as to prolong its elimination time. Artemether was formulated in form of microspheres by solvent evaporation technique and was then formed into the tablet along with the Lumefantrine. Artemether microspheres were prepared and compressed into compressible tablet by direct compression process using the compressible excipients along with Lumefantrine, and was further evaluated for various parameters such as hardness, thickness, weight variation, friability, drug content, in vitro drug release and stability.
2. Alagusundaram M, Chetty M, Umashankar K, Badarinath A, Ramkanth S, Microspheres as a novel drug delivery system, Int J Chem Tech Res, 2009, 1, 526-534.
3. Aulton, ME, Pharmaceutics: The Science of Dosage Form Design, in: Wells, J., Second edition, Pharmaceutical preformulation: the physicochemical properties of drug substances. Churhill Livingstone, Leicester, 2002, 114-136.
4. Balaji A, Kumari H, Kumar U, Development, characterization and evaluation of solid dispersions of artemether and lumefantrine by solvent evaporation method using hydrophilic polymers, Int J Pharn Pharm Sci, 2014, 4, 180-185.
5. Bannister LH, Sherman IW, Plasmodium. Encyclopedia of Life Sciences John Wiley & Sons, 2009, 26:1-10.
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