COMPARATIVE IN VITRO EVALUATION OF BRANDS OF CLOTRIMAZOLE CREAM FORMULATIONS MARKETED IN ETHIOPIA

  • Dereje Debebe Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
  • Tesfaye Gabriel Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
  • Yonas Brhane Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
  • Abraham Temesgen Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
  • Muluken Nigatu Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
  • Tesfa Marew Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
DOI https://doi.org/10.22270/jddt.v8i1.1546

Abstract

The aim of present work was to undertake comparative in vitro quality evaluation of six marketed clotrimazole cream formulations in Ethiopia with respect to physico-chemical properties like viscosity, spreadability, extrudability, pH and drug content. In vitro clotrimazole release from cream formulations was also studied using synthetic cellulose acetate membrane at 37 ºC in a solvent containing methanol and PBS 7.4 in the ratio of 75:25 as receiver medium. The cumulative amounts of the drug released over 12 h (µg mm-2) were analyzed. All clotrimazole cream formulations showed good and smooth homogeneous appearance with white color. The pH of clotrimazole cream formulations ranged from 4-7, which is a physiologically acceptable pH range and in principle devoid of any skin irritation. Clotrimazole content ranged from 90-110%, ensuring the uniformity of the drug content in all formulations. The increase in diameter of clotrimazole cream formulations following the spreadability test was found to range from 4-6 cm. Cream formulation D (Clotri-Denk) exhibited highest viscosity values than other formulations, whereas formulation E (Chinese Clotrimazole BP) showed lowest viscosity value. Cream formulation F (Mycoril) showed better extrudability and spreadability as compared to other formulations. Drug release from all formulations was slow in the first 6 hrs. After the 6th hr, steady drug release continued for formulation D and E. Fast drug release was observed in formulations A (Candid) and B (Candigen), whereas for the formulations C (Canesten), D and E, steady drug release pattern was observed after the 6th hr. It can be concluded that all clotrimazole cream formulations fulfilled the quality criteria of in-house and pharmacopeias specifications.

Keywords: In Vitro Evaluation, Clotrimazole, Cream, Spreadability, Extrudability, Ethiopia

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Author Biographies

Dereje Debebe, Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia
Tesfaye Gabriel, Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Yonas Brhane, Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Abraham Temesgen, Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Muluken Nigatu, Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Tesfa Marew, Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia

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1.
Debebe D, Gabriel T, Brhane Y, Temesgen A, Nigatu M, Marew T. COMPARATIVE IN VITRO EVALUATION OF BRANDS OF CLOTRIMAZOLE CREAM FORMULATIONS MARKETED IN ETHIOPIA. JDDT [Internet]. 14Jan.2018 [cited 19Apr.2024];8(1):17-2. Available from: https://jddtonline.info/index.php/jddt/article/view/1546
Issue
Vol 8 No 1 (2018): VOLUME 8, ISSUE 1, Jan-Feb 2018
Section
Research

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