ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF AERIAL ROOT OF FICUS RELIGIOSA IN ANIMAL MODELS

  • Smita Singh Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
  • Md. Parwez Ahmad Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
  • Deependra Prasad Sarraf Department of Pharmacology, BPKIHS, Dharan, Nepal
  • Chandan Mishra Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
  • Prabin Kumar Singh Department of Paediatrics, Narayani Sub-regional Hospital, Birgunj, Nepal

Abstract

Ficus religiosa commonly found tree in Indian sub-continent has numerous neuro-pharmacological effects including epilepsy in traditional medicine. Therefore, anticonvulsant effect of aqueous aerial root extract of F. religiosa at oral doses 25, 50 and 100 mg/kg was studied  using Maximum electroshock (MES) and Pentylenetetrazole (PTZ) induced seizure models in mice. F. religiosa showed anticonvulsant effect dose dependently in MES & PTZ test. In MES model F. religiosa 100mg/kg significantly (p < 0.05) lowered duration of Tonic hind limb extension. In PTZ model, all three doses of F. religiosa significantly (p < 0.05)   increased latency to convulsion. These findings thus provide scientific evidence in support of the folkloric use of this plant in the management of epilepsy.

Keywords: Anticonvulsant, Ficus religiosa, Maximum electroshock, Pentylenetetrazole, Root

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Author Biographies

Smita Singh, Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal

Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal

Md. Parwez Ahmad, Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
Deependra Prasad Sarraf, Department of Pharmacology, BPKIHS, Dharan, Nepal

Department of Pharmacology, BPKIHS, Dharan, Nepal

Chandan Mishra, Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
Department of Pharmacology, National Medical College Teaching Hospital, Birgunj, Nepal
Prabin Kumar Singh, Department of Paediatrics, Narayani Sub-regional Hospital, Birgunj, Nepal
Department of Paediatrics, Narayani Sub-regional Hospital, Birgunj, Nepal

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Singh S, Ahmad M, Sarraf D, Mishra C, Singh P. ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF AERIAL ROOT OF FICUS RELIGIOSA IN ANIMAL MODELS. JDDT [Internet]. 14Jan.2018 [cited 8Dec.2021];8(1):13-6. Available from: http://jddtonline.info/index.php/jddt/article/view/1543