ANTICONVULSANT EFFECT OF AQUEOUS EXTRACT OF AERIAL ROOT OF FICUS RELIGIOSA IN ANIMAL MODELS
Ficus religiosa commonly found tree in Indian sub-continent has numerous neuro-pharmacological effects including epilepsy in traditional medicine. Therefore, anticonvulsant effect of aqueous aerial root extract of F. religiosa at oral doses 25, 50 and 100 mg/kg was studiedÂ using Maximum electroshock (MES) and Pentylenetetrazole (PTZ) induced seizure models in mice. F. religiosa showed anticonvulsant effect dose dependently in MES & PTZ test. In MES model F. religiosa 100mg/kg significantly (p < 0.05) lowered duration of Tonic hind limb extension. In PTZ model, all three doses of F. religiosa significantly (p < 0.05)Â Â increased latency to convulsion. These findings thus provide scientific evidence in support of the folkloric use of this plant in the management of epilepsy.
Keywords: Anticonvulsant, Ficus religiosa, Maximum electroshock, Pentylenetetrazole, Root
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