A STUDY ON POTENTIAL DRUG - DRUG INTERACTIONS IN MEDICINE DEPARTMENT OF A MULTI SPECIALTY TEACHING HOSPITAL
Aim of study: Drug-drug interaction (DDI) occurs when two or more drugs are simultaneously administered, where the effect of one drug is altered by the concomitant use of another drug. The prospective observational study aimed to assess the potential drug-drug interactions (pDDIs) in general medicine department of a multispecialty teaching hospital.
Material & Methods: Data of all the patients admitted in the general medicine department was collected and analyzed for drug-drug interactions by using drug information resources such as â€œThomson Reuters MICROMEDEXÂ® 2.0 DRUGDEX and drugs.com.
Results: A total of 150 case records were reviewed, 116 (77.33%) cases were identified with 273 potential drug- drug interactions during the study period. Â Â It was observed that out of the 273 DDIs identified, majority 68.13% of the interactions were moderate in severity followed by 19.78% were minor and 12.08% were major. The categorization of onset of drug â€“drug interactions revealed that 53.47% were categorized as â€˜not specifiedâ€™ and the documentation status of drug â€“ drug interactions showed that 56.77% were â€˜fairâ€™ in nature.
Conclusion: The study highlights the need of regular monitoring of drug therapy in identifying and preventing the medications that have the potential to cause drug-drug interactions thereby minimizing the undesirable outcomes in drug therapy and improving the quality of care.
2. Nag KA, Umesh M, Churi S. Assessment of Drug-Drug Interactions in Hospitalized Patients in India. Asian J Pharm Clin Res., 2011; 4(1):62â€“65.
3. Kaliamurthy K, Kumar A, Punniyakotti S, Devanandan P. Study of Drug-Drug Interactions in General Medicine Department of a Tertiary Care Hospital. J App Pharm Sci., 2015; 5(12):122-124.
4. Guthrie B, Makubate B, Hernandez-Santiago V, Creischulte. The Rising Tide of Polypharmacy and Drug-drug Interactions: Population Database Analysis 1995-2010. BMC Medicine, 2015; 74(13):1-10.
5. Pasqualetti G, Tognini S, Calsolaro V, Polini A, Monzani F. Potential Drug-Drug Interactions in Alzheimer Patients with Behavioral Symptoms. Clin Interv Aging, 2015; 10:1457-1464.
6. Baniasadi S, Farzanegan B, Alehashem M. Important Drug Classes Associated with Potential Drug-drug Interactions in Critically Ill Patients: Highlights for Cardiothoracic Intensivists. Ann. Intensive Care, 2015; 44(5):1-8.
7. Ismail M, Iqbal Z, Khattak MB, Javaid A, Khan TM. Prevalence, type and predictors of potential drug-drug interactions in pulmonary ward of a teriary care teaching hospital. Afr J Pharm Pharmacol, 2011; 5(10):1303-1309.
8. Cruciol-Souza JM, Thomson JC. Prevalence of potential drug-drug interactions and its associated factors in a Brazilian teaching hospital. J Pharma Pharmaceut Sci, 2006; 9(3):427-433.
9. Lubinga SJ, Uwiduhaye E, Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital (MRRH) in western Uganda: Prevalence, clinical importance and associated factors. Afr Health Sci, 2011; 11(3):499-503.
10. Umretiya T, Patil NR, Manjunath G, Kumar C. Assessment of Potential Drug-Drug Interactions in the Department of Medicine at Basaweshwara Teaching and General Hospital Gulbarga. RGUHS J Pharm Sci., 2015; 5(3):90-96.
11. Bhagavathula AS, Berhanie A, Tigistu H, Abraham Y, Getachew Y, Khan TM. Prevalence of Potential Drug-Drug Interactions among Internal Medicine Ward in University of Gondar Teaching Hospital, Ethiopia. Asian Pac J Trop Biomed., 2014; 4(1):S204-S208.
12. Patel PS, Rana DA, Suthar JV, Malhotra SD, Patel VJ. A Study of Potential Adverse Drug-Drug Interactions among Prescribed Drugs in Medicine Outpatient Department of a Tertiary Care Teaching Hospital. J Basic Clin Pharma., 2014; 5:44-48.
13. Teixeira JJV, Crozatti MTL, dos Santos CA, Romano-Lieber NS. Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil. PLoS One., 2012; 7(10):1-6.
14. Ahmad A, Khan MU, Haque I, Ivan R, Dasari R, Revanker M Et al. Evaluation of Potential Drug-Drug Interactions in General Medicine Ward of Teaching Hospital in Southern India. J Clin Diagn Res, 2015; 9(2):10-13.
15. Vonbach P, Dubied A, Krahenbuhl S, Beer JH. Prevalence of Drug-Drug Interactions at Hospital Entry and During Hospital Stay of Patients in Internal Medicine. Eur J Intern Med, 2008; 19:413-420.
16. Baxter K, Stockley I. Stockley's Drug Interactions. Ninth Edition. London: Pharmaceutical Press; 2010.P. 15-24.
17. Soher Wardi S, Chogtu B, Faizal P. Surveillance of the Potential Drug-Drug Interactions in the Medicine Department of a Tertiary Care Hospital. J Clin Diagn Res, 2012; 6(7):1258-1261.
18. Dominic A, Joseph J, Augustine RM, Begum R, Nanjwade BK. Study of Drug Use Evaluation on Oral Antihyperglycemic Agents in Type 2 Diabetes Mellitus and Their Potential Drug-Drug Interactions. WJPPS, 2016; 5(7):1884-1896.
19. Kumaraswamy RC, Ramani JU, Ramesh B, Radadiya M, Soumya B, Patel D. Prevalence of Polypharmacy and Drug to Drug Interactions in a Tertiary Care Teaching Hospital. Int. Res. J. Pharm, 2014; 5(10):778-782.
20. Sharma S, Chhetri HP, Alam K. A Study of Potential Drugâ€‘Drug Interactions among Hospitalized Cardiac Patients in a Teaching Hospital in Western Nepal. Indian J. Pharmacol, 2014; 46(2):152-156.
21. Sweileh WM, Sawalha AF, Jaradat NA. Extent of Potential Drug Interactions among Patients Receiving Anti-hypertensive Medications. Saudi Med J, 2005; 26:548-552.
22. Guo JJ, Wu J, Kelton CML, Jing Y, Fan H, Keck PE Et.al. Exposure to Potentially Dangerous Drug-Drug Interactions Involving Antipsychotics. Psychiatr Serv, 2012; 63(11):1080-1088.
23. Nabovati E, Vakili-Arki H, Taherzadeh Z, Saberi MR, Abu-Hanna A, Eslami S. Incidence Rate and Pattern of Clinically Relevant Potential Drug-Drug Interactions in a Large Outpatient Population of a Developing Country. Res Pharm Sci, 2016; 11(3):233-242.
24. Nikolic B, Jankovic S, Stojanov O, Popovic J. Prevalence and Predictors of Potential Drug-Drug Interactions. Cent Eur J Med, 2014; 9(2):348-356.
25. Van Leeuwen RWF, Brundel DHS, Neef C, Van Gelder T, Mathijssen RHJ, Burger DM Et.al. Prevalence of Potential Drugâ€“Drug Interactions in Cancer Patients Treated with Oral Anticancer Drugs. Br. J. Cancer, 2013; 108:1071-1078.
26. Doan J, Zakrzewski-Jakubiak H, Roy J, Turgeon J, Tannenbaum C. Prevalence and Risk of Potential Cytochrome P450â€“Mediated Drug-Drug Interactions in Older Hospitalized Patients with Polypharmacy. Ann. Pharmacother, 2013; 47:324-332.
27. Tavakoli-Ardakani M, Kazemian K, Salamzadeh J, Mehdizadeh M. Potential of Drug Interactions among Hospitalized Cancer Patients in a Developing Country. Iran J Pharm Res, 2013; 12:175-182.
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