TRANSDERMAL PATCH OF RAMIPRIL LOADED CHITOSAN NANOPARTICLES DISPERSED IN CARBOPOL GEL

Yerikala Ramesh, Vadhireddy Sireesha

Abstract


The main aim to improve the systemic bioavailability of Ramipril by the design of transdermal drug delivery based on chitosan nanoparticles dispersed into gels. When chitosan nanoparticles dispersed into gels consisting of poloxamer and carbopol the resulting formulation exhibited thixotropic behavior with a prolonged drug release properties. Our study demonstrated that the designed nanoparticles gel transdermal delivery system has a potential to improve the systemic bioavailability and the therapeutic efficacy of Ramipril loaded chitosan nanoparticles dispersed in carbopol gels. There is no incompatibility between drug and polymers by performing FTIR and DSC. To characterize the rate controlling membrane of transdermal patches. The thickness ranged between TNPGF1 to F9 0.11 ± 0.05 mm to 0.19 ± 0.07 mm, which indicates that they are uniform in thickness. The different batches of formulations weights variations were relatively good uniformity of weight variations among the various batches was observed, with all formulations and ranged from 1.40 ± 1.2% to 1.78 ± 2.0%. The flatness study showed that all the formulations had the same strip length before and after their cuts, indicating 99% flatness. The tensile strength of the TNPGF1 to TNPGF9 shows the 10.14 ± 1.19 to 12.78 ± 2.45 shows the excellent viscosity. The total amount of drug is present in the transdermal patches of TNPGF1 to TNPGF9 was found to be 90.5 ± 0.3 % to 98.5 ± 0.1 %. In-vitro Franz’s diffusion drug Release Studies of among all formulations best formulation TNPGF6. The drug release through the transdermal patches of Ramipril, follows first order kinetics with diffusion controlled mechanism.

Keywords: Ramipril, Nanoparticles, Gels, Folding endurance, Tensile strength.

 


References


Amjad M, Ehtheshamuddin M, Chand S, Hanifa, Sabreesh M, Asia R, Kumar GS, Formulation And Evaluation Of Transdermal Patches Of Atenolol Arpb, 2011; 1(2):109-119

Sujitha B, Krishnamoorthy B, Muthukumaran M Formulation and Evaluation of Piroxicam Loaded Ethosomal Gel for Transdermal Delivery Int J Adv Pharm Gen Res, 2014; 2(1):34-45

Nirja, Jalwal P, Saini J, Mamta, Ritu, Formulation and Evaluation of Transdermal Drug Delivery System For Ibuprofen, IJPPR 2013; 4(2).

Kaur M, Bhatia A, Sethi D, Kaur G, Vig K, Hypoglycemic potential of probiotic DNA loaded chitosan nanoparticles: an in vivo study. Journal of Drug Delivery and Therapeutics, 2017; 7(2):70-76. doi:10.22270/jddt.v7i2.1405

Samy AM, Ghorab MM, Shadeed SG, Mazyed EA, Formulation And Evaluation Of Differefnt Transdermal Drug Delivery Systems Of Ketoprfen, International Journal Of Pharmacy And Pharmaceutical Sciences, 2013; Vol 5, Suppl 2.

Vijayakumar KS, Parthiban S, Senthilkumar GP, T. Tamiz mani, Formulation And Evaluation Of Gliclazide Loaded Ethosomes As Transdermal Drug Delivery Carriers Asian Journal of Research in Biological and Pharmaceutical Sciences. 2014; 2(2):89 - 98.

Anil Reddy B et al., In Vitro Characterization and Evaluation of Transdermal Drug Delivery System for Metoprolol Tartarate Jprhc, 2013; 2(4):325-329.

Ting Li, Changshun Ren, Manli Wang, Ligang Zhao, Ximeng Wang, Liang Fang, Optimized preparation and evaluation of indomethacin transdermal patch Asian Journal of Pharmaceutical Sciences 2007; 2(6):249-259 249.

Yanamandra S, Venkatesan N, Gowda Kadajji V, Wang Z, Manish Issar, Guru V. Betageri, and Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: Case study using a model drug European Journal of Pharmaceutical Sciences, 2014; 64:26-36.

Sveinung G. Ingebrigtsen, Natasaskalko Basnet, Cristiane de Albuquerque Cavalcanti Jacobsen, Ann Mari Holsæter Successful co-encapsulation of benzyl peroxide and chloramphenicol in liposomes by a novel manufacturing method dual asymmetric centrifugation European Journal of Pharmaceutical Sciences, 2017; 97:192-199.

Karthik Y. Janga, RajuJukanti, Ashok Velpula, SharathSunkavalli, Suresh Bandari, PrabhakarKandadi, Prabhakar Reddy Veerareddy Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge European Journal of Pharmaceutics and Biopharmaceutics, 2012; 80:347-357.

ZeljkaVanic, Odon Planinsek, Natasakalko-Basnet, IngunnTho, Tablets of pre- liposome’s govern in situ formation of liposomes: Concept and potential of the novel drug delivery system, European Journal of Pharmaceutics and Biopharmaceutics, 2014; 88:443-454.

Dingler A, Gohla S. Production of solid lipid nanoparticles, scaling up feasibilities. J Microencapsul, 2002, 19: 11–16.

Freitas C, Müller RH.. Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. Eur J Pharm Biopharm, 1999; 47:125-132.

Friedrich I, Reichl S, Muller-Goymann CC. Drug release and permeation studies of nanosuspensions based on solidified reverse micelle solutions, Int J Pharm, 2005; 305:167-175.

Kalam MA, Sultana Y, Samad A, Ali A, Aqil M, Sharma M, Mishra AK, Gelrite-based in-vitro gelation ophthalmic drug delivery system of gatifloxacin, J Disp Sci Tech, 2008; 29:89-96.

Liu J, Gong T, Wang C, Zhong Z, Zhang Z, Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine- based mixed micelles: preparation and characterization. Int J Pharm, 2007; 340:153-162.

Kaur M, Bhatia A, Sethi D, Kaur G, Vig K. Hypoglycemic potential of probiotic DNA loaded chitosan nanoparticles: an in vivo study. Journal of Drug Delivery and Therapeutics, 2017; 7(2):70-76. doi:10.22270/jddt.v7i2.1405

Noha S. El-Salamouni, Ragwa MF, AmalH. El Kamel, Effect of sterilization on the physical stability of brimonidine loaded solid lipid nanoparticles and nanostructured lipid carriers. International journal of pharmaceutics, 2015; 49(6):976-983.

Umaretiya GM, Patel PR, Patel J, formulation and characterization of solid lipidnanoparticles dry powder inhaler containing triamcinolone acetonide. International journal of research in pharmacy and chemistry. 2011; 1(3):221-232.


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