A ROLE OF MACROPHAGES: AN OVERVIEW

Nikita Verma, Swarnlata Saraf

Abstract


The macrophage is a type of phagocytic cell, which is a type of cell those are responsible for detecting, engulfing and destroying pathogens and apoptotic cells. Macrophages are produced through the differentiation of monocytes, which turn into macrophages when they leave the blood. Macrophages also play a role in alerting the immune system to the presence of invaders. Macrophage lineage cells present a remarkably versatile array of functional specializations across vertebrates. As resident cells in virtually all tissues, macrophages aid in maintaining homeostatic environments, and upon infection, are typically one of the first cell types to encounter intruding pathogens, where they orchestrate appropriate immune responses. Another function of macrophages is to alert the immune system to microbial invasion. After ingesting a microbe, a macrophage presents a protein on its cell surface called an antigen, which signals the presence of the antigen to a corresponding T helper cell. Moreover macrophages might be a successful targeting site for targeted drug delivery approaches.

Keywords: macrophages, phagocytic cells, monocytes, immune system


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