FORMULATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET CONTAINING CASSIA TORA MUCILAGE

  • Chandraprakash Dwivedi 1Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India 2Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India
  • S Prakash Rao Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India
  • Amit Roy Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India
  • Swarnlata Saraf University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, (C.G.) 492010, India
  • Ume kulsum Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India
  • Nikita Verma University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, (C.G.) 492010, India
  • Dusmanta Kumar Pradhan Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

Abstract

All the present investigation an attempt has been made to study the formulation and evaluation of matrix tablet of Metformin HCL using natural mucilage of Cassia tora as a release retardant. The matrix tablet was formulated using different drug polymer ratio. The developed formulation of tablet was evaluated for pre-compression and post–compression method. The result of the pre-compression parameter like Bulk density, tapped density, Carr’s index and Hausner’s ratio were found to be with the limits indicating good flow properties of the granules. Swelling index reveals that with increasing mucilage concentration there is increased swelling showing 61% for F-2 at the end of 5 h whereas for F-3 it was around 89.9 % respectively. In- vitro drug release for F3 formulation was found to be 75% at the end of 10 h. With increases in mucilage concentration the drug release from the matrix tablet got retarded. In- vitro, drug release data obtained were fitted to various release model excess the possible mechanism of the drug release. The results of all these parameters are tabulated and depicted graphically in the result and discussion section. IR spectral studies revealed that the drug, polymer and excipients used were compatible.  Drug release profile of all formulation was plotted in different kinetics. The calculated regression coefficients showed a higher r2 value with higuchi equation (r2= 0.958). Hence the release data of the Tablet obeyed higuchi model and release the drug diffusion.

Keywords: Cassia tora, mucilage, granules, drug release, polymer

 

Downloads

Download data is not yet available.

Author Biographies

Chandraprakash Dwivedi, 1Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India 2Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

1Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India

2Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

S Prakash Rao, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India

Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India


Amit Roy, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India
Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Raipur, C.G., 493111, India
Swarnlata Saraf, University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, (C.G.) 492010, India

University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, (C.G.) 492010, India

Ume kulsum, Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

 

Nikita Verma, University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, (C.G.) 492010, India

University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, (C.G.) 492010, India

Dusmanta Kumar Pradhan, Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

Apollo College of Pharmacy, Anjora, Durg, Chhattisgarh 491001, India

References

1. Khullar P, Khar RK, Agarwal SP. Evaluation of Guar Gum in the Preparation of Sustained release Matrix Tablets. Drug Dev Ind Pharm. 1998; 24:1095-9.
2. Lee Vhl, Controlled Drug Delivery Fundamentals and Applications: Introduction, Marcel Dekker, (2nded) Inc, and New York. 1987:29.
3. P.L. Soni, R. Pal, Trends In Carbohydrate Chemistry, 1996; 2:33-44
4. Leon, Shargel (1994), “Comprehensive Pharmacy Review”, 2nd Edition, Harwal Publishing, London, 101-104.
5. Nokano M, Ogata A. In Vitro Release Characteristics of Matrix Tablets: Study Of Karaya Gum and Guar Gum as Release Modulators. Ind. J. Pharm. Sc. 2006; 68(6):824-826.
6. Colombo P, Bettini R, Peppas Na. Drug Diffusion Front Movement Is Important In Drug Release Control Forms Well Able Matrix Tablets. Ind. J. Pharm. Sci.1985; 84:991-7
7. Banker Gs and Anderson Nr. The Theory and Practice of Industrial Pharmacy: Tablet, Lachman, (3rded) Varghese Publishing House, Bombay, 1990, 293-303.
8. Singh K, Walia M, Agarwal G, Harikumar S. Osmotic pump drug delivery system: a noval approach. Journal of Drug Delivery and Therapeutics, 2013; 3(5):156-162. doi:10.22270/jddt.v3i5.636
9. Garg A, Gupta M. Mouth Dissolving Tablets: A Review. Journal of Drug Delivery and Therapeutics, 2013; 3(2):207-214. doi:10.22270/jddt.v3i2.458
10. Kapoor D. Fabrication and characterization of non steroidal anti-inflammatory alginate beads for sustained release using natural polymer. Journal of Drug Delivery and Therapeutics, 2017; 7(2):77-80. doi:10.22270/jddt.v7i2.1401
11. Brahmankar D.m and Jaywalk Sb.Biopharmaceutics and Pharmacokinetics Pharmacokinetics, (2nd Ed) Vallabh Prakashan, Delhi, 2009, 399-401.
12. Lee Vhl. Controlled Drug Delivery Fundamentals and Applications: Influence of Drug Properties On Design, (2nded) Marcel Dekker, Inc, New York. 1987:16-25.
13. Vishvakrama P, Sharma S. Liposomes: An Overview. Journal of Drug Delivery and Therapeutics, 2014; 0:47-55. doi:10.22270/jddt.v0i0.843
14. Keshari A, Tripathi D, Srivastava A, Vishwas R. Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics, 2015; 5(6):43-55. doi:10.22270/jddt.v5i6.1176
15. Kumar Raj, Kohli Kamlesh, Kajal HL, A study of drug prescribing pattern and cost analysis among diabetic patients in a tertiary care teaching institute in north India’. Journal of Drug Delivery and Therapeutics, 2013; 3(2):56-61. doi:10.22270/jddt.v3i2.431
16. Nokano M, Ogata A. Invitro release characteristics of matrix tablets: Study of karaya gum and guar gum as release modulators. Ind. J. Pharm. Sc. 2006; 68(6):824‐826.
17. C.K. Kokate, Practical Pharmacognosy, 4th Ed., Vallabh Prakashan, Delhi, 2006, 123.
18. Kirtiker KR, Basu BD, Indian Medicinal Plants, Volume II, Second Edition. Jayyed Press, New Delhi 1975; 30-45.
19. Anonymous, Ayurvedic Pharmacopoeia of India, Part-II, Vol.-I, 1st Ed., Ministry of Health And Family Welfare Department of Indian System Of Medicine & Homoeopathy, New Delhi, India, 1999, 41.
20. Indian Pharmacopoeia Ministry of Health and Family Welfare. Delhi: Controller of Publications; 1996
21. Rao N, Laharika M, Kistayya C. Design and development of simvastatin gastroretentive tablets for controlled release. Journal of Drug Delivery and Therapeutics, 2017; 7(1):30-36. doi:10.22270/jddt.v7i1.1353
22. Banker G.S., Rhodes C.T., Modern Pharmaceutics, Drug And Pharmaceutical Science, 2nd Edn, Dekker Marcel:501-527
23. Kumar S.K.P., Debjit B., Srivastava S., Paswan S., Dutta As., Sustained Release Drug Delivery System Potential, The Pharma Innovation. 2012; 1(2):48-60.
24. Remington: The Science and Practice Of Pharmacy, Published By: Wolter Kluwer Health (India): 2006; 21st Edn, Vol 1:939-964.
25. Chugh I, Seth N, Rana AC, Gupta S, Oral Sustain Release Drug Delivery System: An Overview, International Research Journal of Pharmacy. 2012; 3(5):57-62.
26. Dir S., Badola A., Sharma D., Sustained Release Matrix Technology and Recent Advance in Matrix Drug Delivery System: A Review. International Journal of Drug Research Andtechnology, 2013; 3(1):12-20.
27. Lieberman H.A., Lachman L., Kanig J L., The Theory and Practice of Industrial Pharmacy, 3rd Edn, Published By: Varghese Publishing House:430-456
28. Banker G.S., Rhodes C.T., Modern Pharmaceutics, Drug and Pharmaceutical Science, 2nd Edn, Dekker Marcel: 501-527.
29. Dusane A.R., Gaikwad P.D., Bankar V.H, Pawar S.P., A Review on Sustain Release Technology, International Journal Research In Ayurvedic And Pharmacy. 2011; 2(6):1701-1708.
30. Gupta M.M., Ray B., A Review on: Sustained Release Technology, International Journal Of Therapeutic Applications. 2012; (8):1-23.
31. Ratnaparkhi M.P., Gupta J.P., Sustained Release Oral Drug Delivery System – An Overview International Journal of Pharma Research & Review. 2(3):11-21, 2013
32. Vyas S.P, Khar R.K., Controlled Drug Delivery Concept and Advances, 2nd Edn Delhi: 2012; 1-53.
Statistics
35 Views | 40 Downloads
How to Cite
Dwivedi, C., Rao, S., Roy, A., Saraf, S., kulsum, U., Verma, N., & Pradhan, D. (2017). FORMULATION AND CHARACTERIZATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLET CONTAINING CASSIA TORA MUCILAGE. Journal of Drug Delivery and Therapeutics, 7(6), 66-75. https://doi.org/10.22270/jddt.v7i6.1520

Most read articles by the same author(s)