A REVIEW ON THERAPEUTIC APPLICATIONS OF PHYTOSOMES

  • Prajkta Satish Chivte National Facility for Biopharmaceuticals, G N Khalsa College, Matunga, Mumbai 400019.
  • Vinal Shivram Pardhi National Facility for Biopharmaceuticals, G N Khalsa College, Matunga, Mumbai 400019.
  • Vineeta Anil Joshi National Facility for Biopharmaceuticals, G N Khalsa College, Matunga, Mumbai 400019.
  • Ajitha Rani Department of Chemistry, G N Khalsa College, Matunga, Mumbai 400019.

Abstract

Ethnobotanical plants have been used in the treatment of various diseases since antiquity. The phytoconstituents have pharmacological activities such as anti-tumor, anti-inflammatory, antinociceptive, anti-obesity, thermoregulatory effects, cardioprotective, anti-asthmatic, anti-diabetic, anti-oxidant, hepatoprotective and potent CNS activities. Various drug delivery systems like liposomes, niosomes, transferosomes, ethosomes, phytosomes, colloidosomes etc. are developed in order to carry the drug to the site of action without its metabolism. The major concern with respect to phytoconstituents having different chemical nature is its bioavailability and effective dosage concentration which could be overcome by means of phytosome technology. Chemically, phytosomes are vesicles of phospholipids bonded with a hydrogen bond to phytochemical/s. The current review highlights the major therapeutic applications of phytosomes till date. The review discusses about a latest and novel drug delivery system viz. “Phytosome technology†whereby major emphasis has been provided on the different therapeutic applications of phytosomes and its crucial role in managing the conventional complications that are encountered for the delivery of phytoconstituents. Applications of phytosomes such as enhancing bioavailability, anti-cancer and anti-oxidant agent, transdermal delivery, wound healing capacity etc. have been discussed. The comparison between the therapeutic activities of free drug and its phytosomes indicates that the complex provides various advantages over the conventional treatments.

Keywords: Phytosome, Phytoconstituents, Bioavailability, Cancer, Anti-oxidant.

Keywords: Drug Delivery, Phytosomes, Therapeutics

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Author Biographies

Prajkta Satish Chivte, National Facility for Biopharmaceuticals, G N Khalsa College, Matunga, Mumbai 400019.

National Facility for Biopharmaceuticals, G N Khalsa College.

MSc. (Bioanalytical Sciences)

Vinal Shivram Pardhi, National Facility for Biopharmaceuticals, G N Khalsa College, Matunga, Mumbai 400019.

National Facility for Biopharmaceuticals, G N Khalsa College.

PhD Scholar (Bioanalytical Sciences),

Protein Purification and Characterisation Laboratory In-charge.

Vineeta Anil Joshi, National Facility for Biopharmaceuticals, G N Khalsa College, Matunga, Mumbai 400019.

National Facility for Biopharmaceuticals, G N Khalsa College.

MSc. (Biotechnology)

Ajitha Rani, Department of Chemistry, G N Khalsa College, Matunga, Mumbai 400019.

Department of Chemistry.

Associate Professor and Research guide (Bioanalytical Sciences)

References

1. More Minakshi S, Shende Mulchand A, Kolhe Deul B, J. N. M., Herbosomes: herbo-phospholipid complex an approach for absorption enhancement, Int. J. Biol. Pharm. Res., 2013, 4(9), 634–639.
2. Kuamwat Radhey Shyam, Mruthunjaya K, G. M. K.,Preparation, characterisation and antioxidant activities of gallic-acid phospholipid complex, Int. J. Res. Pharm. Sci.,2012, 2, 138–148.
3. Pathak K. & Das R. J., Herbal Medicine-A Rational Approach in Health Care System, Int. J. Herb. Med. IJHM,2013, 1(13), 86–89.
4. Tripathy S, Patel DK, Barob L, Naira SK, A review on phytosomes, their characterization, advancement & potential for transdermal application, Journal of Drug Delivery and Therapeutics, 2013; 3(3):147-152
5. Jing Li, Xulin Wang, Ting Zhang, Chunling Wang, Zhenjun Huang, Xiang Luo, Yihui Deng, A review on phospholipids and their main applications in drug delivery systems, Asian J. Pharm. Sci.,2104, 10(2), 81–98.
6. Anju Dhiman, Arun Nanda, S. A., Novel Herbal Drug Delivery System (NHDDS) : the need of hour, Int. Conf. Environ. Energy Biotechnol,2013, 51(26), 139–142.
7. Jadhav S. M., Morey P., Karpe M. M. & Kadam V., Novel vesicular system: An overview, J. Appl. Pharm. Sci.,2012, 2(1), 193–202.
8. Saraf S., Khan, J., Alexander A., Ajazuddin & Saraf S., Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives, J. Control. Release, 2013,168(1), 50–60.
9. Amit P., Tanwar Y. S., Rakesh S. & Poojan P., Phytosome : Phytolipid Drug Delivery System for Improving Bioavailability of Herbal Drug, J. Pharm. Sci. Biosci. Res., 2013, 3(2), 51–57.
10. Mazumder A., Dwivedi A., Du Preez J. L. & Du Plessis J., In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex, Int. J. Pharm., 2016, 498, 283–293.
11. Qunyou Tan, Shan Liu, Xueliang Chen, Mingjun Wu, Hong Wang, Huafeng Yin, Dan He, Huarong Xiong, and Jingqing Zhang, Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability, AAPS PharmSciTech, 2012, 13(2), 534–547.
12. Franceschi, Federico, Giori, A., Phospholipid compleses of olive fruits or leaves extracts having improved bioavailability, 2006, 1, 1–8.
13. Vora A. K., Londhe V. Y. & Pandita N. S., Preparation and characterization of standardized pomegranate extract-phospholipid complex as an effective drug delivery tool, J. Adv. Pharm. Technol. Res.,2015, 6(2), 75–80.
14. Kwan K. C., Oral bioavailability and first-pass effects, Drug Metab. Dispos.,1997, 25(12), 1329-1336.
15. Moscarella S. et al., Therapeutic and antilipoperoxidant effects of silybin-phosphatidylcholine complex in chronic liver disease: Preliminary results, Curr. Ther. Res., 1993, 53(1), 98–102.
16. Rasaie S., Ghanbarzadeh S., Mohammadi M. & Hamishehkar H., Nano Phytosomes of Quercetin : A Promising Formulation for Fortification of Food Products with Antioxidants. Pharm. Sci., 2014, 20, 96–101.
17. B. Demir, F. B. Barlas, E. Guler, P. Z. Gumus, M. Can, M. Yavuz, H. Coskunolbef and S. Timur, Gold nanoparticle loaded phytosomal systems: synthesis, characterization and in vitro investigations, RSC Adv., 2014,4, 34687.
18. Panda V. S. & Naik S. R., Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: A biochemical and histoarchitectural evaluation, Exp. Toxicol. Pathol., 2008, 60, 397–404.
19. Naik S. R. & Panda V. S., Hepatoprotective effect of Ginkgoselect Phytosome ® in rifampicin induced liver injurym in rats : Evidence of antioxidant activity, Fitoterapia, 2008, 79, 439–445.
20. Jain P. K., Kharya M. & Gajbhiye A., Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage, Drug Dev. Ind. Pharm., 2013, 39(11), 1840–1850.
21. Jain P. K., Khurana N., Pounikar Y., Gajbhiye A. & Kharya M. D., Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system, J. Liposome Res., 2013, 23(2), 110–8.
22. Raina H., Soni G., Jauhari N., Sharma N. & Bharadvaja N., Phytochemical importance of medicinal plants as potential sources of anticancer agents, Turk. J. Botany, 2014, 38, 1027–1035.
23. Shalini S., Kumar R. R. & Birendra S., Antiproliferative effect of Phytosome complex of Methanolic extact of Terminalia arjuna bark on Human Breast Cancer Cell Lines (MCF-7), Int J Drug Dev Res.,2015, 7(1), 173–182.
24. D. Galloa, S. Giacomellia, C. Ferlinia, G. Raspaglioa, P. Apollonioa, S. Prisleia, A. Rivab, P. Morazzonib, E. Bombardellib, G. Scambia, Antitumour activity of the silybin-phosphatidylcholine complex , IdB 1016 , against human ovarian cancer, Eur. J. Cancer, 2003, 39, 2403–2410.
25. Narges Mahmoodi, Nasrin Motamed, Seyed Hassan Paylakhi, The Comparison of The Effects of Silybin and Silybin-Phosphatidylcholine on Viability and ESR Expression in Human Breast Cancer T47d cell line, Cell J., 2014; 16(3):299–308.
26. Mehdi Sabzichi, Hamed Hamishehkar, Fatemeh Ramezani, Simin Sharifi, Maryam Tabasinezhad, Mohammadbagher Pirouzpanah1, Parisa Ghanbari3, Nasser Samadi., Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling, Asian Pacific J. Cancer Prev., 2014; 15(13):5311–5316.
27. Das M. K. & Kalita B., Design and Evaluation of Phyto-Phospholipid Complexes (Phytosomes) of Rutin for Transdermal Application, J. Appl. Pharm. Sci., 2014; 4(10):51–57.
28. Bombardelli, Patri, P. Complexes of saponins with phosphlipids and pharmaceutical and cosmetic compositions containing them. 9 (1988).
29. Lakshmi Devi, S. & Divakar M. C. Wound healing activity studies of Wrightia arborea phytosome in rats. Hygeia J. drugs Med. 2012; 4(2):87–94.
30. Yamila B. Gándola, Sebastián E. Pérez, Pablo E. Irene,Ana I. Sotelo, Johanna G. Miquet, Gerardo R. Corradi, AdrianaM. Carlucci, and LorenaGonzalez1. Mitogenic effects of phosphatidylcholine nanoparticles on MCF-7 breast cancer cells. Biomed Res. Int. 2014.
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Chivte P, Pardhi V, Joshi V, Rani A. A REVIEW ON THERAPEUTIC APPLICATIONS OF PHYTOSOMES. JDDT [Internet]. 13Sep.2017 [cited 3Mar.2021];7(5):17-1. Available from: http://jddtonline.info/index.php/jddt/article/view/1513