NOVEL MULTIPARTICULATE DRUG DELIVERY SYSTEM OF CARVEDILOL AS ANTIHYPERTENSIVE DRUG

Abdul Nasir Kurnool, Rakesh Kumar Jat, C NARENDRA

Abstract


The main objectives of present work was to design and evaluate pellets of Carvedilol in order to increase patient compliance and therapeutically benefits. The pellets were made by the sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in stomach for long time. Hence sodium bicarbonate and hydroxyl propyl methyl cellulose are the key ingredients of this dissertation work. In vitro release trials were evaluated in response to check release of drug from the drug coated spheres. The release pattern of batches T1 to T6 was observed to vary due to variation in the concentration of HPMC 5cps, low substituted HPC and PVP K30. The trials T1-T3 showed the slow drug release due to combination of PVP K30 with low substituted HPC and HPMC 5cps; while the formulation T4-T6 showed the good release behavior as compare to T1-T3.

Keywords: Carvedilol, Multiparculate, Pellets, TLC, HPLC.



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