INSIGHT IN TO APPLICATIONS OF THERMAL SINTERING TECHNIQUE IN NDDS SPECIALLY GRDDS

  • Shaikh Nawaj Siraj Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • Saleem Mau Patel Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • G J Khan Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • K I Molvi Department of Pharmaceutical Sciences, IBN Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia
  • PATEL M Siddik Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, Indiaa
  • Shaoor Ahmad Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Abstract

Oral route the most popular route of administration for systemic action .Oral conventional drug delivery has following limitation of unpredictable gastric emptying rate, short gastro intestinal transit time, and inter subject variability leads in to less bioavailability so goal of drug delivery were not properly achieved by conventional dosage forms. So there is need of sustained drug delivery. The sustained drug delivery can be achieved by matrix tablet wherein a solid drug is dispersed in an insoluble matrix. The matrix tablets can be prepared by wet granulation method or modern thermal sintering technique. Sintering concept in the pharmaceuticals technology is very novel. The term sintering means fusion of particles or formation of welded bonds between particles of polymer. Sintering is a method of heating the material in a sintering furnace below its melting point (solid-state sintering) until its particles adhere to each other. In this process, polymer particles undergo fusion or formation of welded bonds between the each particle. Controlled release oral dosage forms were developed by sintering the polymer matrix to its glass transition temperature. The use of sintering technique adds to the effectiveness of polymers to extend the release of drug from formulation depending upon the duration and temperature of sintering. Sintering technique enhanced the extent of drug retardation from the systems studied is short enough for it to be a suitable candidate for SR formulation. The term sintering means fusion of particles or formation of welded bonds between particles of polymer. The SR oral dosage forms can be developed by sintering the polymer Gastroretentive drug delivery system is facing many challenges which can be overcome by upcoming newly sintered technique.   This review article explains about various aspects of sintering technique also highlighted some research work on sintered technology.

Keywords: Oral route, sintering, sustain, thermal, drug delivery, research work

 

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Author Biographies

Shaikh Nawaj Siraj, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
Saleem Mau Patel, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

G J Khan, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

K I Molvi, Department of Pharmaceutical Sciences, IBN Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

Department of Pharmaceutical Sciences, IBN Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia

PATEL M Siddik, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, Indiaa

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Shaoor Ahmad, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

References

1. Patil H, Tiwari RV, Repka MA. Recent advancements in mucoadhesive floating drug delivery systems: A mini-review. Journal of Drug Delivery Science and Technology. 2016; 31:65-71.
2. Pawar VK, Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. Drug delivery. 2011; 18(2):97-10.
3. Shaikh S, Molvi K I. Current trends in gastroretentive floating bioadhesive drug delivery system. International journal of pharmacy and pharmaceutical research. 2016; 6(1):356-67.
4. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Tropical Journal of Pharmaceutical Research. 2008; 7(3):1055-66.
5. Deshpande AA, Rhodes CT, Shah NH, Malick AW. Controlled-release drug delivery systems for prolonged gastric residence: An overview. Drug Development and Industrial Pharmacy. 1996; 22(6):531-9. 1.
6. Whishead L, Fell JT, Collett JH. Development of gastroretentive dosage form. European Journal of Pharmaceutical Sciences. 1996; 4:S182.
7. Patwekar T S, Rode R B, A Review on Sintering Method in Pharmaceutical Sciences, Asian J. Pharm. Tech, 2014; 4(2): 106-109.
8. Amol R .Bodke, Smita S. Aher, R. B. Saudagar A Review on Sintering Technique in Pharmaceutical Sciences. International Journal of ChemTech Research. 2017; 10(5): 210-215.
9. Rao BS. et al. Studies on release of rifampicin from sintered matrix tablet. Indian Journal of pharmaceutical science. 2001; 63(5):371-378.
10. Chandan Mohant sintering technique in pharmaceutical sciences: a brief review. IJPT | 2011; 3(1 ):799-806
11. Rao BS. et al. Design and Evaluation of Eudragit RL 100 sintered matrix tablets. Indian J.Pharm Sci. 2004; 66(2): 202-207.
12. Tahseen, G. Sri Vyshnavi, D. Mounika, D. Shina Shankar Prasad A review on matrix drug delivery system. ejpmr, 2017; 4(2), 448-453.
13. Deepika B, Begum S, Faria Patel DM. et al. Design of controlled release non-erodible polymeric matrix tablet using microwave oven-assisted sintering technique. Journal of controlled release, 2002; 84:99-114.
14. Arve SPV, Battuwar A, Hajare R, formulation and evaluation of gastroretentive drug delivery system of carevedilol phosphate by sintering technology. World journal of pharmacy and pharmaceutical science.2016; 5(4):959-978.
15. Mohanty C, Subrahmanyam KV, Mohammad AS, Jena TK, Thermal Sintering Technique: A Novel Strategy Used in the Design of Gastro Retentive Floating Matrix Tablets of Nicardipine HCl and Its Evaluation. International Journal of Pharma Research and Health Sciences.2016; 4 (1):1004-1009.
16. Lakshmi PK, Husnien Ali M, formulation and evaluation of sintered matrix tablets of lamotrigine. IAJPS 2015; 2(11):1518-1524.
17. RP Rao, Shivpuje S, Godbole R, Shirsath C, design and evaluation of sustained release matrix tablets using sintering technique. Int J Pharm Pharm Sci, Vol 8, Issue 2, 115-121.
18. Bhagwat RR, Vaidya II, Formulation of Verapamil Hydrochloride Matrix Granules by Sintering Technique and its Evaluation. Global Journal of Medical research: B Pharma, Drug Discovery, Toxicology and Medicine. 2014; 14(1).
19. Meka VS, Ambedkar SS, Sreenivasa NR, Janaki BR, VenkataRMK. Thermal sintering: a novel technique used in the design, optimization and biopharmaceutical evaluation of propranolol HCl gastric floating tablets. Drug Dev Ind Pharm, 2014; 40(1): 33–45.
20. Parvathi M. et al. Formulation and evaluation of sintered matrix tablets of metformin hydrochloride and it’s comparison over unsintered matrix tablets. International Journal of Research in Pharmacy and Chemistry, 2013; 3(3): 521-530.
21. Meka VS et al; Thermal sintering: a novel technique in the design of gastroretentive floating tablets of propranolol HCl and its evaluation; Invest Clin; 2012; 53(3): 223-236.
22. Sameer S, Chowdary K.A., Nagoba S, Nangargekar S, “sintered matrix tablets of diltiazem hydrochloride. Int J App Pharm, 2011; 3(3):16-19.
23. Seshagiri B, Chowdary KA, Deepthi Priya Y, “formulation and evaluation of sintered gastro retentive tablets of glizipide”, International journal of pharmacy and pharmaceutical sciences, 2011; 3(4).
24. Bhamre V. et al. Stability study of stavudine sintered matrix tablet. International Research Journal of pharmacy. 2013; 4(1):182-186.
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Siraj S, Patel S, Khan G, Molvi K, Siddik P, Ahmad S. INSIGHT IN TO APPLICATIONS OF THERMAL SINTERING TECHNIQUE IN NDDS SPECIALLY GRDDS. JDDT [Internet]. 22Sep.2017 [cited 3Mar.2021];7(5):109-13. Available from: http://jddtonline.info/index.php/jddt/article/view/1510