INSIGHT IN TO APPLICATIONS OF THERMAL SINTERING TECHNIQUE IN NDDS SPECIALLY GRDDS
Oral route the most popular route of administration for systemic action .Oral conventional drug delivery has following limitation of unpredictable gastric emptying rate, short gastro intestinal transit time, and inter subject variability leads in to less bioavailability so goal of drug delivery were not properly achieved by conventional dosage forms. So there is need of sustained drug delivery. The sustained drug delivery can be achieved by matrix tablet wherein a solid drug is dispersed in an insoluble matrix. The matrix tablets can be prepared by wet granulation method or modern thermal sintering technique. Sintering concept in the pharmaceuticals technology is very novel. The term sintering means fusion of particles or formation of welded bonds between particles of polymer. Sintering is a method of heating the material in a sintering furnace below its melting point (solid-state sintering) until its particles adhere to each other. In this process, polymer particles undergo fusion or formation of welded bonds between the each particle. Controlled release oral dosage forms were developed by sintering the polymer matrix to its glass transition temperature. The use of sintering technique adds to the effectiveness of polymers to extend the release of drug from formulation depending upon the duration and temperature of sintering. Sintering technique enhanced the extent of drug retardation from the systems studied is short enough for it to be a suitable candidate for SR formulation. The term sintering means fusion of particles or formation of welded bonds between particles of polymer. The SR oral dosage forms can be developed by sintering the polymer Gastroretentive drug delivery system is facing many challenges which can be overcome by upcoming newly sintered technique.Â Â This review article explains about various aspects of sintering technique also highlighted some research work on sintered technology.
Keywords: Oral route, sintering, sustain, thermal, drug delivery, research work
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