FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLET OF ONDANSETRON HYDROCHLORIDE BY COPROCESS EXCIPIENTS

  • Shaikh Nawaj Siraj Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • Shaikh Heena Kausar Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • G J Khan Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • Tajammul Khan Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Abstract

Recent development in fast disintegrating technology mainly works to improve the quality of these delicate dosage forms without affecting their integrity. Current investigations deal with the formulation of fast dissolving tablet of Ondansetron HCl with the effect of different co-processed excipients by using ball mill that disintegrates in oral cavity on contact with saliva & thereby improve therapeutic efficacy because the mannitol was stick to dies and punch therefore ball mill is used to prepare co ground mixtures of crospovidone and mannitol to improve the compatibility and stability of product. The Fast disintegrating tablets of Ondansetron HCl were prepared by direct compression method using different synthetic superdisintegrant such as Crospovidone, and natural superdisintegranst such as Karaya gum and Fenugreek gum in different concentration. The FTIR, DSC analysis revealed that the Betacyclodextrin and superdisintegrants used were compatible with Ondansetron HCl. A complex of Betacyclodextrin and Ondansetron HCl was successfully formed in 1:2 ratios. Disintegration time decrease with increase in the concentration o superdisintegrant. Among all formulation, containing Karaya Gum as superdisintegrants is fulfilling all the parameters satisfactorily. In vitro release studies that almost 98.88% of the drug was released from all the formulation were within 15 minutes. Best Formulation F6 showed faster drug release within 7 minutes in comparison to other formulation. ThE result shows that Co-processing of excipients is the most suitable approach for formulation of Fast dissolving tablet.

Keywords: Coprocess, Fast disintegrating tablets, Ball mill, Disintegration time, Mannitol etc.

 

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Author Biographies

Shaikh Nawaj Siraj, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
Shaikh Heena Kausar, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

G J Khan, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Tajammul Khan, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

References

1. Tomar M, Sinha AR, Singh AK, Process and Development of Co-Processed Excipient Silicified Microcrystalline Cellulose and Manufacture Paracetamol Tablet by Direct Compression. Int. J. Pharm. Sci. Rev. Res., 2017; 42(1):191-196.
2. Nautiyal U, Singh S, Singh R, Gopal, Kakar S, Fast Dissolving Tablets As A Novel Boon: A Review: Journal Of Pharmaceutical, Chemical And Biological sciences May 2014; 2(1):05-26.
3. More S, Ghadge T, Fast Disintegrating Tablets: An Overview Asian J. Res. Pharm. Sci. 2013; 3:47-55.
4. Mali RR, Gupta S, Goel V, Novel Study In Fast Dissolving Drug Delivery System: A Review: Indian Journal Of Pharmaceutical And Biological Research (Ijpbr), 2015; 3(1):93-107.
5. Nautiyal U, Aggarwal P, Mali RR, A Review On: Fast Dissolving Tablet Int. J Rec. Adv. Sci. Tech, 2015; 2(2):20-28.
6. Marwaha M, Sandhu D, Marwaha RK. Coprocessing of excipients: a review on excipient development for improved tabletting performance, International Journal of Applied Pharmaceutics, 2010; 2(3):41-42.
7. Shirwaikar AA. Novel coprocessed excipients of Mannitol and microcrystalline cellulose for preparing fast dissolving tablets of glipizide. Indian J Pharm Sci, 2007; 69:633-9.
8. Chougule AS, Dikpati A, Trimbake T. Formulation Development Techniques of Co-processed Excipients. Journal of Advanced Pharmaceutical Sciences, 2012; 2(2):231-249.
9. Chowdary KPR, Franklin Israel S and Satyanarayana AR. Preparation, Characterization and Evaluation of Starch - PEG 1500 Co-Processed Excipient as Directly Compressible Vehicle in Tablet Formulations. International Journal of Comprehensive Pharmacy, 2012; 11(4):1-4.
10. Chowdary KPR and Ramya K. Recent Research on Co-Processed Excipients for Direct Compression-A Review. International Journal of Comprehensive Pharmacy, 2013; 2(01):1-5.
11. Fu Y, Yang S, Jeong SH, Kimura S, Park K, Orally Fast Disintegrating Tablets: Developments, Technologies, Taste-Masking and Clinical Studies, Critical Reviewsâ„¢ In Therapeutic Drug Carrier Systems, 2004; 21(6):433-475.
12. Kumar S, Kaur H, Mishra PB, Vashisht N, Vimalarora, Mouth Dissolving Tablets: A Convenient Novel Dosage Form - A Review,International Journal of Pharmaceutical Research And Development, 2013; 5(08):021-032.
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Siraj S, Kausar S, Khan G, Khan T. FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING TABLET OF ONDANSETRON HYDROCHLORIDE BY COPROCESS EXCIPIENTS. JDDT [Internet]. 22Sep.2017 [cited 3Mar.2021];7(5):102-8. Available from: http://jddtonline.info/index.php/jddt/article/view/1498

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