SUPERCRITICAL FLUID TECHNOLOGY: AN INNOVATIVE APPROACH USED TO ENHANCE SOLUBILITY OF WATER INSOLUBLE DRUGS
Abstract
Certain techniques are used for the preparation of solid dispersions and used to enhance the solubility of water insoluble drugs. One of its techniques is supercritical fluid technology that is used for the preparation of solid dispersions. The present aim of this technique is to provide the recent advances in the use of supercritical fluids for the preparation of solid dispersion and for pharmaceutical substances with particular attention to drug delivery systems. Basically, a “supercritical fluid†can be defined as it enters in the pure substance when both temp. & pressure above its critical P&T. In the SCF techniques, there are certain solvents like CO2, N2O used as the supercritical fluid. This innovative technique is highly promising and approachable for the future applications in pharmaceutical industries.
Keywords: Supercritical fluids, solubility, solid dispersion, drug delivery, and Applications.
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References
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2. Shah DP, Patel B, Shah C, Nanosuspension technology: A innovative slant for drug delivery system and permeability enhancer for poorly water soluble drugs, Journal of Drug Delivery and Therapeutics, 2015; 5(1):10-23
3. Asadujjaman MD, Mishuk AU, Novel approaches in lipid based drug delivery systems, Journal of Drug Delivery and Therapeutics, 2013; 3(4):124-130
4. Mundhe AV, Cocrystalization: an alternative approach for solid modification, Journal of Drug Delivery and Therapeutics, 2013; 3(4):166-172
5. Gupta RB. Supercritical fluid technology for particle engineering, In: Gupta RB, Kompella UB editpors. Nanoparticle technologies for drug delivery, Volume 159 in Drugs and Pharmaceutical Sciences, Marcel Dekker, Inc, 2006, p 53-84.
6. Misra A, Jinturkar K, Patel D, Lalani J, Chougule M. Recent advances in liposomal dry powder formulations: preparation and evaluation. Expert Opin Drug Delivery. 2009; 6:71-89.
7. Pasquali I, Bettini R. Are pharmaceutics reallygoing supercritical? Int J Pharm. 2008; 364:176-187.
8. Duarte ARC, Duarte CMM, editors. Current Trends of the Supercritical Fluid Technology in the Pharmaceutical, Nutraceutical and Food Processing Industries. Bentham Books. eISBN: 978-1-60805-046-8, 2009
9. Pasquali I, Bettini R, Giordano F. Supercritical fluid technologies: an innovative approach for manipulating the solid-state of pharmaceuticals. Adv Drug Deliv Rev. 2008; 60:399-410.
10. Liu H, Pan WS, Zhou LL, Guo H. Supercritical fluid technology and its application in pharmaceutics. Acta pharmaceu Sinica. 2007; 41:1123-1129.
11. Bhardwaj. L, Sharma P.K., Visht S, Garg V.K., Kumar N A review on methodology and application of supercritical fluid technology in pharmaceutical industry. Der Pharmacia Sinica, 2010; 1 (3):183-194
12. Van Hees T, Piel G, Evrard B, Otte X, Thunus T, Delattre L. Application of supercritical carbon dioxide for the preparation of a piroxicam-beta-cyclodextrin inclusion compound. Pharm Res. 1999; 16(12):1864-1870.
13. Brunner G, In: Brunner G (ed.), Gas extraction. Steinkopff Darmstadt, Springer, New York, USA, 1994.
14. Gupta R.D, J Pharma Sci Res, 2008; 6 (2): 200-240
15. Krukonis V, Supercritical fluid nucleation of difficult to comminute solids, Proc. Annual Meeting AIChE, paper 140f, t-124, 1998.
16. Philips, E.M., Stella. V.J. Rapid Expansion from supercritical solutions: application to pharmaceutical Processes, Int J. Pharm, 1993; 94:1-10.
17. Meziani M.J, Pathak P, Beachman F, Allard L.F., Sun Y.P. Nanoparticle Formation in rapid expansion of water- in-supercritical carbon dioxide microemulsion into liquid solution, J. Supercritcal Fluids, 2001; 34:91-97.
18. Hanna .M, York P, WO95/01221, 1995.
19. York. P, Hanns. M, Shekunov Y.P., Humphreys, G.O. Microfine particles formation by SEDS (Solution enhanced Dispersion by Supercritical Fluids): scale up by design, Proc. Resp. Drug Delivery VI, 1998; 169-175.
20. Ker. J, Knez. S, Sen. P, Int J Pharm, 1999; 182, 1:33-39.
21. Moneghini M, Kikic I, Voinovich D, Perissutti B, Filipovic-Grcic J, Int J Pharm., 2001; 222(1):129-138.
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Kaur T, Sharma P, Kumar S. SUPERCRITICAL FLUID TECHNOLOGY: AN INNOVATIVE APPROACH USED TO ENHANCE SOLUBILITY OF WATER INSOLUBLE DRUGS. JDDT [Internet]. 13Sep.2017 [cited 3Mar.2021];7(5):22-6. Available from: http://jddtonline.info/index.php/jddt/article/view/1495
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