Adane Teshome Kefale, Beza Dereje Tefera, Tessema Tsehay Biru


Background: Drugs have become one of an essential component of health care systems worldwide. However, there is a concern for their safety. Adverse drug reaction (ADR) is common during usual clinical practice and it is associated with increased morbidity, hospitalization and mortality.

Objective: To assess knowledge, attitude, and practice of health care professionals (HCPs) towards ADRs reporting at inpatient wards of Tikur Anbessa Specialized Hospital (TASH), Ethiopia.

Methods: Hospital based descriptive cross-sectional study was conducted among 280 HCPs at the inpatient wards of TASH. The data required for the present study was collected using self-administered structured questionnaire and samples were selected through both stratified and systematic random sampling methods, where the type of profession was used as a stratum. The collected data was analyzed using SPSS version 21.00 for the window.

Results: Of 280 HCPs to whom the questionnaire initially administered, 213 respondents filled and returned the questionnaire, giving a response rate of 76.1%, and were included in the analysis. The study revealed that 78.9% and 47.9% of HCPs have poor knowledge and negative attitude towards ADR reporting respectively.  Among respondents, 38% of HCPs encountered patient with ADR, 90.2% of them reported the ADR they encountered, of them only 10.8% were reported to Ethiopian food, medicine, and health care administration and control authority, a regulatory body for receiving and monitoring ADR throughout the country.

Conclusion: HCPs in TASH had poor knowledge, attitude and practice towards ADRs reporting. The hospital should devise strategies to enhance detection and reporting of ADRs.


World Health Organization. Policy perspectives on medicines Pharmacovigilance: ensuring the safe use of medicines. WHO, Geneva, Switzerland. 2004

Kharkar M, Bowalekar S. Knowledge, attitude and perception/ practices (KAP) of medical practitioners in India towards adverse drug reaction (ADR) reporting. Perspect Clin Res. 2012;3(3):90–4.

Food, Medicine, Health care administration and control authority of Ethiopia. Guideline for Adverse Drug Events Monitoring ( Pharmacovigilance ). FMHACA, Addis Ababa Ethiopia, 2014.

Agarwa R, Daher AM, Ismail NM. Knowledge, Practices and Attitudes Towards Adverse Drug Reaction Reporting by Private Practitioners from Klang Valley in Malaysia. Malasys J Med Sci. 2013;20(2):52–61.

Jordan Food and Drug administration. Guidelines for Detecting & Reporting Adverse Drug Reactions: Individual Case Safety Reports For Healthcare professionals.JFDA. 2014

Drug administration and control authority. Report on the assessment of health care providers knowledge, attitude and practice on Advers drug reaction reporting and its monitoring. Addis Ababa, Ethiopia. 2008.

Boeker EB, de Boer M, Kiewiet JJS, Lie-a-huen L, Dijkgraaf MGW, Boermeester MA. Occurrence and preventability of adverse drug events in surgical patients: a systematic review of literature. BMC Health Serv Res. 2013;13(1):364.

Sharma A, Kellarai A. Pharmacovigilance and adverse drug reaction reporting perspectives among interns and postgraduates of a teaching hospital. J Pharmacol Pharmacother. 2014;5(4):248–50.

Eland IA, Belton KJ, Grootheest ACV, Meiners AP, Rawlins MD, Stricker BHC. Attitudinal survey of voluntary reporting of adverse drug reactions. Br J Clin Pharmacol. 1999;48(1):623–7.

Bäckström M, Ekman E, Mjörndal T. Adverse drug reaction reporting by nurses in Sweden. Eur J Clin Phamacology. 2007;63:613–8.

Mulatu WN, Worku A. Pharmacovigilance Assessment of Knowledge, Attitude and Practice of Health Professionals towards Adverse Drug Reaction Reporting and Factors Associated with Reporting. J Pharmacovigil. 2014;2(4).

Bhagavathula AS, Elnour AA, Jamshed SQ, Shebab A. Health Professionals Knowledge, Attitudes and Practices about Pharmacovigilance in India : A Systematic Review and Meta- Analysis. PLoS One. 2016;11(3):e0152221.

Ermias A, Gurmesa G, Mesfin M, Mengistu A. Adverse Drug Reaction Monitoring in Ethiopia : Analysis of case reports, 2002-2007. Ethiop J Heal Dev. 2011;25(2):168–73.

Fadare JO, Enwere OO, Afolabi AO, Chedi BAZ, Musa A. Knowledge, Attitude and Practice of Adverse Drug Reaction Reporting among Healthcare Workers in a Tertiary Centre in Northern Nigeria. Trop J Pharm Res. 2011;10(3):235–42.

Katusiime B, Semakula D, Lubinga SJ, Katusiime B. Adverse drug reaction reporting among health care workers at Mulago National Referral and Teaching hospital in Uganda. Afr Health Sci. 2015;15(4):1308–17.

Tariku B, Mulisa E, Tesema S. Health Professionals’ Knowledge, Attitude And Practices Towards Adverse Drug Reaction Reporting In Nekemte Hospital, Ethiopia. MD-Medical Data. 2015;7(1):041–6.

Adimasu A. Nurses knowledge related to adverse drug reaction reporting and associated factors at Felegehiwot Referral Hospital and University of Gondar Teaching Hospital , Northwest Ethiopia. Am J Heal Res. 2014;2(4):164–70.

Angamo MT, Tesfa A, Wabe NT. Knowledge, Attitude and Practice of Adverse Drug Reaction Reporting among Health Professionals in Southwest Ethiopia. TAF Prev Med Bull. 2012;11(4):397–406.

World Health Organization. The importance of Pharmacovigilance: safety monitroring of medicinal products. WHO. 2002.

Teshale C, Melaku R. Knowledge, attitude and practice of Health professionals towards Adverse drug reaction reporting in Jimma Zone hospitals, Southwest Ethiopia. Pharmacologyonline. 2010;2:308–15.

Alem Denekew. Knowledge, attitude and practice of adverse drug reaction reporting and affecting factors among health care providers working in ART clinics of public health facilities in Addis Ababa. Addis Ababa University, masters thesis, 2014.

Ayalnesh Goshime. Assessment of Knowledge, Attitude and Practices on Adverse Drug Reaction Reporting among Pharmacy Personnel Working at Community Pharmacy, Addis Ababa, Ethiopia. Addis Ababa University. masters thesis. 2015.

Full Text: PDF


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

ISSN: 2250-1177  This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.