ANTI-ARTHRITIC EVALUATION OF SOME TRADITIONALLY USED MEDICINAL PLANTS IN FCA INDUCED ARTHRITIS IN RATS

  • Om Prakash Tiwari Bhagwant University, Ajmer, Rajasthan, India
  • Manoj Sharma School of pharmacy, Jiyaji University, Gwalior, (M.P.), India

Abstract

Aim of Study: The main of study is to evaluate the anti-arthritic activity of some Traditionally Used Medicinal Plants in FCA Induced Arthritis in Rats.

Material & Methods: All the selected medicinal plants were extracted by using methanol using soxhlet apparatus. Arthritis was induced by FCA in rats and body weight; hematological parameters were measured at the end of experiment.

Results: The assessment made on the 21st day showed that the N. arbor-tristis and A. scholaris treatments at both doses (low and high) had moderately significant and highly significant effect and reduced (p< 0.01& p<0.001). N. arbor-tristis, A. scholaris had highly significant effects (p<0.001) in recovery of RBCs and haemoglobin. They also showed highly significant effects on decrease in WBCs and ESR. B. monosperma and B. diffusa extract treated groups, also showed moderately significant effects as compared to arthritic group.

Conclusion: By comparing the results of the selected plants in FCA induced arthritis, it could be concluded that methanolic extracts of Nyctanthes arbor-tristis, Alstonia scholaris and Butea monosperma have most potent and highly significant anti-arthritic activity.

Keywords: Nyctanthes arbortristis, Butea monosperma, Alstonia scholaris, Arthritis, Arthritic Assessment

 

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Author Biographies

Om Prakash Tiwari, Bhagwant University, Ajmer, Rajasthan, India

Research Scholar Bhagwant University, Ajmer, Rajasthan, India

Manoj Sharma, School of pharmacy, Jiyaji University, Gwalior, (M.P.), India

School of pharmacy, Jiyaji University, Gwalior, (M.P.), India

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Tiwari O, Sharma M. ANTI-ARTHRITIC EVALUATION OF SOME TRADITIONALLY USED MEDICINAL PLANTS IN FCA INDUCED ARTHRITIS IN RATS. JDDT [Internet]. 13Sep.2017 [cited 27Jan.2021];7(5):74-9. Available from: http://jddtonline.info/index.php/jddt/article/view/1475