FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF CEFOTAXIME USING RAFT FORMING APPROACH

Ramesh Yerikala, Venkata Prasad Pudi, K Saravanakumar, Sireesha Vadhireddy

Abstract


The cefotaxime is a broad-spectrum cephalosporin antibiotic. It is mainly used in the treatment of bacterial infections. Cefotaxime is a suitable candidate for controlled release administration due to its short elimination time 1 hour. The main aim of the present investigation is to increase the gastric residence time by preparing floating drug delivery by using raft forming approach thereby improving bioavailability. The prepared Cefotaxime floating drug delivery by using raft forming approach were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time, In-vitro dissolution studies and buoyancy lag time. Floating tablets were formulated using direct compression technique. Various polymers are used in the formulation they Microcrystalline cellulose used as binder, HPMC K15M, Guargum used as hydrophilic polymers, Chitosan, Sodium bicarbonate was incorporated as an effervescent substance, Sodium alginate used as viscous gel forming agent, Magnesium streate used as lubrication, talc was used as diluent. The formulated Cefotaxime tablet to be evaluated the following parameters as follow Weight variation (mg), Hardness, Thickness, Friability, Drug content uniformity, Floating lag time, the in vitro cumulative amount of drug released was shown the F7 is 99.28% within 45 minutes the comparative studies with marketed formulations F7 show the better results.

Keywords: Cefotaxime, Direct compression, Raft forming, floating drug delivery system.


References


Deshbhratar RM, Studies on Formulation and In-vitro Evaluation of Gastro Retentive Drug Delivery System of Carbamazepine; International Journal of Chem Tech Research 2010; 2(1):108-113.

Dey S, UV Spectrophotometric Determination of Cefixime in Bulk and its Dosage Form, Journal of Pharmacy Research, 2012; 5(12):5419-5422.

Janakidevi S, Design and Optimization of Cefixime Trihydrate Sustained Matrix Tablets Using Different Polymers, International Research Journal of Pharmacy, 2014; 7(5):619-625.

Streubel A, Siepmann J, Bodmeier R, Drug Delivery to the upper small intestine window using Gastro retentive technologies. Curr Opin Pharmacol, 2006; 6:501-508.

Rubinstein, MH, Physiological Pharmaceutical: Biological barriers to the drug absorption. Chichester, U.k: Ellis Horwood. 1989, P.47-70.

Whitehead L, Fell JT and Collett JH. Development of a gastroretentive dosage form. Eur J Pharm Sci, 1996; 4:182-188.

Birajdar shiv Prasad M, BhusnureOG, S. Mulaje S, formulation and evaluation of fast disintegrating losartan tablets by formal experimental design, international journal of research and development in pharmacy and life sciences, 2014; 3(1):1136-1150.

Devareddy S, Krishnarajan D, Manivannan R, Senthilkamar N. Formulation and Evaluation of Losartan Potassium and Hydrochloriazide Conventional Release Tablets, International Research Journal of Pharmacy, 2012; 3(6):159-164.

Gehan balata, Formulation and Evaluation of Gastro-retentive Floating Tablet of Nizatidine. International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6(5):423-429.

Haranadh CH, Lokeshreddy M, Vaseedhar B, Sabareesh M, Umasankar K. Formulation and evaluation of hydrogel based oral controlled drug delivery system for losartan potassium. International Journal of Research in Pharmaceutical and Nano sciences, 2014; 3(3):190-199.

Patel J, Patel A, Sheth Z, Development of Floating Tablet Containing Roxatidine Acetate by Statistical Optimization Technique, International Journal of Pharmaceutical Science, 2014; 3(5):201-210.

Jagadale S K, Patil P S and Navele R, Formulation and Evaluation of Orally Disintergrating Tablet of Losartan Potassium by Direct Compression Method. Research journal of pharmaceutical biological and chemical sciences, 2013; 4(4):127-135.

Janimini M, Shrivastava B, Tanwar V.S, Formulation and Evaluation of Effervescent Floating Matrix Tablet of Losartan Potassium, International Journal of Pharmaceutical Innovations, 2011; 1(5):82-87.

Katyayini S, Sellappanvelmurugan, Formulation and Evaluation of Effervescent Floating Tablets of Losartan Potassium, International Journal of Pharmacy and Pharmaceutical sciences, 2013; 5(3):559-565.

Latha K, Uhumwangho MU, Sunil SA, Srikanth MV, Ramana murthy KV, Formulation and Evaluation of Oral Time Release Tablets of Losartan Potassium Using Natural Gum and its Solid Characterization, 2012; 4(5):89-95.

Manjula B, B. Mohammed Ishaq, C. Hari Kumar, Usha Rani G. Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Ketoprofen. Scholars Research Library, Der Pharmacia Lettre, 2010; 2(3):197-208.

Janimini M, Tanwar YS, Srivastava B, Formulation and Evaluation of Gastro Retentive Drug Delivery System of Losartan Potassium, International Current Pharmaceutical Journal, 2012; 2(1):11-17.

Chandira M, Bhowmik D, Chiranjib,.Jayakar B, Formulation Evaluation of Gastro retentive Drug Delivery System of Gastroprokinetic drug Itopride hydrochloride, International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2(1):53-65.

Janimini M, Shrivastava B, Tanwar V.S, Formulation and Evaluation of Effervescent Floating Matrix Tablet of Losartan Potassium, International Journal of Pharmaceutical Innovations, 2011; 1(5): 82-87.

Katyayini S, Sellappanvel Murugan, Formulation and Evaluation of Effervescent Floating Tablets of Losartan Potassium, International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5(3):559-565.

Keshari A, Tripathi DPK, Srivastava A, Vishwas R, Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics. 2015; 5(6):43-55

Janimini M, Tanwar YS, Birendrasrivastava, Formulation and Evaluation of Gastro Retentive Drug Delivery System of Losartan potassium, International Current Pharmaceutical Journal, 2012; 2(1):11-17.

Manjula B, Formulation and Evaluation Gastro Retentive Floating Drug Delivery System of Ketoprofen, Scholars research library, 2010; 2(3):197-208.

Margret chandira R, Debit Bhowmik, Chiranji B, and B. Jayakar, Formulation & Evaluation of Gastro Retentive Drug Delivery System of Gastroprokinetic drug Itopride hydrochloride, International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2(1):53-65.


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