VALIDATED COLORIMETRIC METHODS FOR THE ESTIMATION OF TENELIGLIPTIN IN TABLETS

  • PG Sunitha Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,
  • R Karthikeyan Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,
  • B Ranjith Kumar Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,
  • S Muniyappan Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,

Abstract

Two simple sensitive and precise methods A and B were developed for the estimation of teneligliptin in bulk drug as well as in pharmaceutical dosage form. Method A is based on the formation of a red colored chromogen by reaction of teneligliptin with potassium thiocyanate in presence of ferric chloride, which has an absorption maximum at 554nm.   Method B is based on the formation of an orange colored complex by complexation reaction of teneligliptin with 2, 2’- bipyridyl in the presence of ferric chloride which has an absorption maximum at 421nm. The proposed methods are statistically validated and found to be useful for the routine determination of teneligliptin in tablets.

Keywords: Teneligliptin, Colorimetry, Tablets, Validation

 

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Author Biographies

PG Sunitha, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,

Department of Pharmaceutical Chemistry,  College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

R Karthikeyan, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,

Department of Pharmaceutical Chemistry,  College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

B Ranjith Kumar, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,

Department of Pharmaceutical Chemistry,  College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

S Muniyappan, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu,

Department of Pharmaceutical Chemistry,  College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

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How to Cite
1.
Sunitha P, Karthikeyan R, Ranjith Kumar B, Muniyappan S. VALIDATED COLORIMETRIC METHODS FOR THE ESTIMATION OF TENELIGLIPTIN IN TABLETS. JDDT [Internet]. 15Jul.2017 [cited 8Dec.2021];7(4):38-0. Available from: http://jddtonline.info/index.php/jddt/article/view/1467