LIQUISOLID COMPACTS: A PROMISING APPROACH FOR SOLUBILITY ENHANCEMENT

  • Janardhan D Pawar Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301
  • R S Jagtap Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301
  • R C Doijad Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
  • S V Pol Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
  • J R Desai Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
  • V V Jadhav Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
  • S R Jagtap Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301

Abstract

At present 40% of the drugs within the development pipelines, and approximately 60 % of the drugs coming directly from synthesis area unit poorly soluble.  Solubility is one of the important parameter to obtain desired concentration of drug in systemic circulation. Liquisolid compacts technique is a new and promising approach to overcome this consequence and that can change the dissolution rate of water insoluble drugs and increase the bioavailability of the drugs. This technique is an efficient method for formulating water insoluble and water soluble drugs. This technique relies upon the admixture of drug loaded solutions with applicable carrier and coating materials. Liquisolid system is characterized by flow behaviour, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra-red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in-vitro release and in-vivo evaluation. This review article explains the preparation, classification and application of liquisolid system.

Key word: Liquisolid system, water insoluble drug, carrier material, coating material

 

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Author Biographies

Janardhan D Pawar, Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301

Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301, India

R S Jagtap, Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301
Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301, India
R C Doijad, Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra, India
S V Pol, Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra, India
J R Desai, Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra, India
V V Jadhav, Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra
Department of Pharmaceutics, Shree Santkrupa College Of Pharmacy, Ghogaon, Karad, Maharashtra, India
S R Jagtap, Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301
Department of Pharmaceutics, Annasaheb Dange College of Pharmacy. Ashta, Dist. Sangli, Maharashtra-416 301, India
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How to Cite
1.
Pawar J, Jagtap R, Doijad R, Pol S, Desai J, Jadhav V, Jagtap S. LIQUISOLID COMPACTS: A PROMISING APPROACH FOR SOLUBILITY ENHANCEMENT. JDDT [Internet]. 15Jul.2017 [cited 8Dec.2021];7(4):6-1. Available from: http://jddtonline.info/index.php/jddt/article/view/1466