FORMULATION DEVELOPMENT AND EVALUATION OF 5-FLUROURASIL AND ECONAZOLE GEL USING RICE BRAN WAX
Abstract
Besides delivering drug to the body, a drug delivery system aims to improve patient compliance, patient acceptance. The dosage forms available for the delivery of topical agents include ointment, paste, lotion, moisturizing cream and powder. However, Gel is more preferable due to their properties. Present research work is attempted to develop gel by using rice bran wax. Rice bran wax is the vegetable wax extracted from rice bran oil. The oil generally contains 2–6% wax. However it is assumed that on an average it contains 3% wax. Physicochemical tests such as globule size, evaluation of the intrinsic viscosity and homogeneity of Gel products, have been traditionally used to provide reasonable evidence of consistent product performance. However, for the purposes of these studies, the final gel products were characterized for their clarity, pH, viscosity, spread ability, skin irritation test and in vitro diffusion studies using standard procedure. All the results match with official specifications.
Keywords: Gel, Rice Bran Wax, Econazole, 5-Fluorouracil
Â
Â
Downloads
References
2. Adair CR. Rice chemistry and technology. In: Houston DF, editor. Production and Utilization of rice. 2nd ed. St. Paul, MN: AACC; 1972:15-44.
3. Neha K, Nirmala HSL, Insitu gelling system: A Review, J Drug Del and Therapeutics. 2014; 4(4):93-103
4. Mujahid M, Ahmad L, Ahmad M, Synthesis of ZnO nanogel for the treatment of superficial skin microbial infections, Journal of Drug Delivery and Therapeutics. 2017; 7(2):58-61
5. Farooqi. Herbal skin care formulation and process for the preparation thereof, U.S. Patent US 6368639, 2002.
6. Pandya K, Aggarwal P, Dashora A, Sahu d, Garg R, Pareta LK, Menaria M, Joshi B, Formulation and evaluation of oral floatable in-situ gel of ranitedine hydrochloride, Journal of Drug Delivery and Therapeutics. 2013; 3(3):90-97
7. Saarinen-Savolainen P, Jarvinen T, Taipale H, Urtti A. Method for evaluating drug release from liposomes in sink conditions. Int J Pharm 1997; 159:27-33.
8. Kulkarni SK, Jain NK. Pharmacological and pharmacokineti c studies on marketed gel formulations of nimesulide, India n Drugs 2001; 38:63â€66.
9. Lachman, Leon; et al; "The Theory and Practice of Industrial Pharmacy†Varghese publication, India, 3rd edition 1987: 534- 562.
10. Sachan A, Gupta A, Arora M. "Formulation & characterization of nanostructured lipid carrier (NLC) based gel for topical delivery of etoricoxib." Journal of Drug Delivery and Therapeutics, 2016; 6(2):4-13.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.