FORMULATION DEVELOPMENT AND EVALUATION OF 5-FLUROURASIL AND ECONAZOLE GEL USING RICE BRAN WAX

Rajeev Malviya, MD Khirsagar, AV Chandewar

Abstract


Besides delivering drug to the body, a drug delivery system aims to improve patient compliance, patient acceptance. The dosage forms available for the delivery of topical agents include ointment, paste, lotion, moisturizing cream and powder. However, Gel is more preferable due to their properties. Present research work is attempted to develop gel by using rice bran wax. Rice bran wax is the vegetable wax extracted from rice bran oil. The oil generally contains 2–6% wax. However it is assumed that on an average it contains 3% wax. Physicochemical tests such as globule size, evaluation of the intrinsic viscosity and homogeneity of Gel products, have been traditionally used to provide reasonable evidence of consistent product performance. However, for the purposes of these studies, the final gel products were characterized for their clarity, pH, viscosity, spread ability, skin irritation test and in vitro diffusion studies using standard procedure. All the results match with official specifications.

Keywords: Gel, Rice Bran Wax, Econazole, 5-Fluorouracil

 

 


References


Bodmier R, Hermann J. Encyclopedia of Pharmaceutical Techonology. Vol. 16. In: Swarbrick J, Boylan JC, editors. Waxes. New York: Marcel Deckker, Inc.; 1997: 335-361.

Adair CR. Rice chemistry and technology. In: Houston DF, editor. Production and Utilization of rice. 2nd ed. St. Paul, MN: AACC; 1972:15-44.

Neha K, Nirmala HSL, Insitu gelling system: A Review, J Drug Del and Therapeutics. 2014; 4(4):93-103

Mujahid M, Ahmad L, Ahmad M, Synthesis of ZnO nanogel for the treatment of superficial skin microbial infections, Journal of Drug Delivery and Therapeutics. 2017; 7(2):58-61

Farooqi. Herbal skin care formulation and process for the preparation thereof, U.S. Patent US 6368639, 2002.

Pandya K, Aggarwal P, Dashora A, Sahu d, Garg R, Pareta LK, Menaria M, Joshi B, Formulation and evaluation of oral floatable in-situ gel of ranitedine hydrochloride, Journal of Drug Delivery and Therapeutics. 2013; 3(3):90-97

Saarinen-Savolainen P, Jarvinen T, Taipale H, Urtti A. Method for evaluating drug release from liposomes in sink conditions. Int J Pharm 1997; 159:27-33.

Kulkarni SK, Jain NK. Pharmacological and pharmacokineti c studies on marketed gel formulations of nimesulide, India n Drugs 2001; 38:63‐66.

Lachman, Leon; et al; "The Theory and Practice of Industrial Pharmacy” Varghese publication, India, 3rd edition 1987: 534- 562.

Sachan A, Gupta A, Arora M. "Formulation & characterization of nanostructured lipid carrier (NLC) based gel for topical delivery of etoricoxib." Journal of Drug Delivery and Therapeutics, 2016; 6(2):4-13.


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