NANOPARTICLES CARRYING NATURAL PRODUCT FOR DRUG DELIVERY

  • Suhui Ni Department of Pharmacy, China Pharmaceutical University, Nanjing, PR China, 211100

Abstract

Camptothecin, Doxorubicin, Paclitaxel, Vincristine, and Etoposide are the naturally occurring anti-cancer drugs that are analyzed in this analysis. It is found that these compounds can be developed as nanomedicine. It has been determined from analyses that nanoparticles are useful in targeted drug delivery to address some of the innate issues. However, there are certain limitations that are found in nanomedicine. There is a need for more research to develop effective drugs in the future. A more detailed analysis of the same has been done in the following.

Keywords: Camptothecin, Doxorubicin, Paclitaxel, Vincristine, Etoposide, Targeted drug delivery, mechanism of action, toxicity, limitations

Camptothecin, Doxorubicin, Paclitaxel, Vincristine, and Etoposide are the naturally occurring anti-cancer drugs that are analyzed in this analysis. It is found that these compounds can be developed as nanomedicine. It has been determined from analyses that nanoparticles are useful in targeted drug delivery to address some of the innate issues. However, there are certain limitations that are found in nanomedicine. There is a need for more research to develop effective drugs in the future. A more detailed analysis of the same has been done in the following.

Keywords: Camptothecin, Doxorubicin, Paclitaxel, Vincristine, Etoposide, Targeted drug delivery, mechanism of action, toxicity, limitations

Downloads

Download data is not yet available.

Author Biography

Suhui Ni, Department of Pharmacy, China Pharmaceutical University, Nanjing, PR China, 211100

Department of Pharmacy, China Pharmaceutical University, Nanjing, PR China, 211100

References

1. Hamidi M, Azadi A, and Rafiei P. Hydrogel nanoparticles in drug delivery. Advanced drug delivery reviews. 2008, 60: 1638-1649
2. Cheng X. Developing organic and inorganic nanomedicine for cancer therapy. Journal of Drug Delivery and Therapeutics. 2017, 7: 1-4
3. Cheng X, and Lee R J. The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery. Adv Drug Deliv Rev. 2016, 99: 129-137; doi: 10.1016/j.addr.2016.01.022.
4. Cheng X, Liu Q, Li H, Kang C, Liu Y, Guo T, et al. Lipid Nanoparticles Loaded with an Antisense Oligonucleotide Gapmer Against Bcl-2 for Treatment of Lung Cancer. Pharm Res. 2017, 34: 310-320; doi: 10.1007/s11095-016-2063-5.
5. Duan Y, Pei K, Cai H, Tu S, Cheng X, Zhang Z, et al. Strategy of integrated evaluation on treatment of traditional Chinese medicine as ‘interaction of system to system’and establishment of novel fuzzy target contribution recognition with herb-pairs, a case study on Astragali Radix-Fructus Corni. Molecular and Cellular Endocrinology. 2016, 434: 219-237
6. Duan Y, Pei K, Cai H, Tu S, Zhang Z, Cheng X, et al. Bioactivity evaluation-based ultra high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry and novel distinction of multi-subchemome compatibility recognition strategy with Astragali Radix-Fructus Corni herb-pair as a case study. Journal of pharmaceutical and biomedical analysis. 2016, 129: 514-534
7. Liu Z, Jiao Y, Wang Y, Zhou C, and Zhang Z. Polysaccharides-based nanoparticles as drug delivery systems. Advanced drug delivery reviews. 2008, 60: 1650-1662
8. Sun Y, and Kang C. Self-Assembly of Peptides into Hydrogel. Journal of Organic & Inorganic Chemistry. 2016,
9. Sun Y, Kang C, Liu F, and Song L. Delivery of Antipsychotics with Nanoparticles. Drug Development Research. 2016, 77: 393-399
10. Sun Y, Kang C, Yao Z, Liu F, and Zhou Y. Peptide-Based Ligand for Active Delivery of Liposomal Doxorubicin. Nano LIFE. 2016, 6: 1642004
11. Sun Y, Kang C, Zhang A, Liu F, Hu J, Zhong X, et al. Co-delivery of dual-drugs with nanoparticle to overcome multidrug resistance. European Journal of BioMedical Research. 2016, 2: 12-18
12. Waller A P, George M, Kalyanasundaram A, Kang C, Periasamy M, Hu K, et al. GLUT12 functions as a basal and insulin-independent glucose transporter in the heart. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2013, 1832: 121-127
13. Soppimath K S, Aminabhavi T M, Kulkarni A R, and Rudzinski W E. Biodegradable polymeric nanoparticles as drug delivery devices. Journal of controlled release. 2001, 70: 1-20
14. Hsiang Y-H, Hertzberg R, Hecht S, and Liu L. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. Journal of Biological Chemistry. 1985, 260: 14873-14878
15. Li Q-Y, Zu Y-G, Shi R-Z, and Yao L-P. Review camptothecin: current perspectives. Current medicinal chemistry. 2006, 13: 2021-2039
16. Kang C, Qin J, Osei W, and Hu K. Regulation of protein kinase C-epsilon and its age-dependence. Biochemical and Biophysical Research Communications. 2017, 482: 1201-1206
17. Kang C, Sun Y, Wang M, and Cheng X. Nanosized camptothecin conjugates for single and combined drug delivery. European Journal of BioMedical Research. 2016, 2: 8-14
18. Kang C, Sun Y, Zhu J, Li W, Zhang A, Kuang T, et al. Delivery of Nanoparticles for Treatment of Brain Tumor. Current Drug Metabolism. 2016, 17: 745-754
19. Li H, Cheng X, Liu Y, Lee Y B, Kim D J, Ahn C-h, et al. Folate receptor-targeted lipid coated albumin nanoparticles (F-LCAN) for therapeutic delivery of RX-0201 (Archexin®), an antisense oligonucleotide against Akt-1. 2016,
20. Li H, Quan J, Zhang M, Yung B C, Cheng X, Liu Y, et al. Lipid-Albumin Nanoparticles (LAN) for Therapeutic Delivery of Antisense Oligonucleotide against HIF-1alpha. Mol Pharm. 2016, 13: 2555-2562; doi: 10.1021/acs.molpharmaceut.6b00363.
21. Chen Y, Bian Y, Sun Y, Kang C, Yu S, Fu T, et al. Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors. PeerJ. 2016, 4: e2140
22. Davis M E. Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin. Advanced drug delivery reviews. 2009, 61: 1189-1192
23. Guo X K, Sun H P, Shen S, Sun Y, Xie F L, Tao L, et al. Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III. Chemistry & biodiversity. 2013, 10: 73-85
24. Liu Z-l, Zhang R-m, Meng Q-g, Zhang X-c, and Sun Y. Discovery of new protein kinase CK2 inhibitors with 1, 3-dioxo-2, 3-dihydro-1 H-indene core. MedChemComm. 2016, 7: 1352-1355
25. Sun H, Zhu J, Chen Y, Sun Y, Zhi H, Li H, et al. Docking Study and Three‐Dimensional Quantitative Structure‐Activity Relationship (3D‐QSAR) Analyses and Novel Molecular Design of a Series of 4‐Aminoquinazolines as Inhibitors of Aurora B Kinase. Chinese Journal of Chemistry. 2011, 29: 1785-1799
26. Qian W-Y, Sun D-M, Zhu R-R, Du X-L, Liu H, and Wang S-L. pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release. Int J Nanomed. 2012, 7: 5781-5792
27. Wang Y, Dou L, He H, Zhang Y, and Shen Q. Multifunctional nanoparticles as nanocarrier for vincristine sulfate delivery to overcome tumor multidrug resistance. Molecular pharmaceutics. 2014, 11: 885-894
28. Liu F, Sun Y, Kang C, and Zhu H. Pegylated Drug Delivery Systems: From Design to Biomedical Applications. Nano LIFE. 2016, 6: 1642002
29. Qiao H, Fang D, Chen J, Sun Y, Kang C, Di L, et al. Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease. Drug Delivery. 2017, 24: 233-242
30. Song L, Kang C, Sun Y, Huang W, Liu W, and Qian Z. Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells. Cellular Physiology and Biochemistry. 2016, 40: 443-452
31. XU S-h, Chen K, CHEN M-l, ZHOU P-p, HE G-w, CUI Y-j, et al. Dynamic expression of AQP4 in early stageof ischemia/reperfusion rats and cerebral edema. Chinese Pharmacological Bulletin. 2016: 1433-1441
32. Xue X, Zhao N-Y, Yu H-T, Sun Y, Kang C, Huang Q-B, et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking. PeerJ. 2016, 4: e2757
33. Shin J-Y, Yang Y, Heo P, Lee J-C, Kong B, Cho J Y, et al. pH-responsive high-density lipoprotein-like nanoparticles to release paclitaxel at acidic pH in cancer chemotherapy. Int J Nanomedicine. 2012, 7: 2805-2816
34. Han R, Sun Y, Kang C, Sun H, and Wei W. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. Journal of Drug Targeting. 2017, 25: 140-148
35. Yang Z, Xie J, Zhu J, Kang C, Chiang C, Wang X, et al. Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation. Journal of Controlled Release. 2016, 243: 160-171
36. Yao Z, Sun Y, and Kang C. Structure and Self-Assembly of Multicolored Naphthalene Diimides Semiconductor. Nano LIFE. 2016, 6: 1642007
37. Zhong X, Sun Y, Kang C, and Wan G. The theory of dielectrophoresis and its applications on medical and materials research. European Journal of BioMedical Research. 2017, 2: 7-11
38. Du J-Z, Du X-J, Mao C-Q, and Wang J. Tailor-made dual pH-sensitive polymer–doxorubicin nanoparticles for efficient anticancer drug delivery. Journal of the American Chemical Society. 2011, 133: 17560-17563
Statistics
352 Views | 339 Downloads
How to Cite
1.
Ni S. NANOPARTICLES CARRYING NATURAL PRODUCT FOR DRUG DELIVERY. JDDT [Internet]. 14May2017 [cited 8Dec.2021];7(3):73-5. Available from: http://jddtonline.info/index.php/jddt/article/view/1425