SIMULTANEOUS STIMATION OF ASPIRIN AND OMEPRAZOLE (Y0SPRALA) IN BULK BY UV-SPECTROSCOPY
In India, there are roughly 30 million heart patients and two lakh surgeries are being performed every year. YOSPRALA-a new emerging drug approved by USFDA in September 2016 to treat Ischemic stroke, prophylaxis and gastric ulcer prophylaxis. The active ingredients present are Aspirin and Omeprazole.Hence ana attempt is made to develop a new analytical method for Simultaneous estimation of Aspirin and Omeprazole using methanol as solvent The Absorption maxima of Aspirin and Omeprazole was at 224nm and 251.8nm respectively. Linearity range for aspirin was 0.5-25Âµg/ml with regression co-efficient-099 and omeprazole was 1-8Âµg/ml with regression coefficient 0.992. The method was validated for precision and %RSD was less than 1.5% for both aspirin and omeprazole. The proposed method was statistically validated for standard deviation, relative standard deviation.coefficient of variance and the results were within the limits. Hence the above method was simple, cost effective, robust and can be used for routine analysis in in pharmaceutical preparations.Keywords: Yosprala, Aspirin and Omeprazole, UV spectroscopy.
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