PHARMACOGNOSTIAL EVALUATION AND PHYTOCHEMICAL SCREENING OF THEVETIA PERUVIANA

  • Rupesh Jitpure NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh
  • Savita Yadav NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh
  • Ronak Kurmi NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh
  • Kehar Dhaker NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India
  • Mithun Bhowmick NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh
  • Jagdish Rathi NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India

Abstract

Flowers of Plant Thevetia peruviana (Pers.) K. Schum.were reported to possess good medicinal value in traditional system of medicine, the present investigation deals with Macroscopic, Microscopic and preliminary phytochemical investigation of flowers of Thevetia peruviana which includes pharmacognostical parameters, physiochemical parameters like ash values, extractive values and moisture content. The total ash, acid insoluble ash, waterâ€soluble ash values and sulfated ash were observed to be 3.50%, 1.60%, 1.30% and 1.20% w/w respectively. Alcohol soluble, waterâ€soluble and Ether soluble extractive values of the flowers were observed to be 8.30%, 4.80%, and 3.70% respectively. Powdered flowers were also subjected to fluorescence analysis with different chemicals. Phytochemical investigation of powdered drug revealed the presence of Alkaloids, glycosides, tannins, phenolic compounds, proteins, essential oils, gums, mucilage and fixed oils. The main aim of the present investigation is to study the macro, microscopic and some other pharmacognostic characters and physicochemical standards of flowers of Thevetia peruviana Pers. which could be used to prepare a monograph for the proper identification of the plant.

Keywords: Thevetia peruviana, Phytochemical, Fluorescence analysis, Physical evaluation.

 

 

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Author Biographies

Rupesh Jitpure, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh

NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh

Savita Yadav, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh

NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh

Ronak Kurmi, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh

NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh

Kehar Dhaker, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India

NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India

 

Mithun Bhowmick, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh
NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh
Jagdish Rathi, NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India
NRI Institute of Pharmaceutical Sciences, Bhopal, Madhya Pradesh, India

References

1. Shannon D. Langford & Paul J. Boor "Oleander toxicity: an examination of human and animal toxic exposures". Toxicology, 1996; 109(1):1–13.
2. Bose TK, Basu RK, Biswas B, De JN, Majumdar BC, Datta S. "Cardiovascular effects of yellow oleander ingestion". J Indian Med Assoc, 1996; 97(10):407–410.
3. Kohls S, Scholz-Böttcher BM, Teske J, Zark P, Rullkötter J. "Cardiac glycosides from Yellow Oleander (Thevetia peruviana) seeds". Phytochemistry, 2012; 75:114–27.
4. Rajapakse S. "Management of yellow oleander poisoning". Clinical Toxicology, 2009; 47:12-18.
5. Roberts D.M.; Southcott E.; Potter J.M.; Roberts M.S.; Eddleston M.; Buckley N. "Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal". Therapeutic Drug Monitoring, 2009; 28(6):784–792.
6. Bandara V.; Weinstein S.A.; White J.; Eddleston M. "A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning". Toxicon, 2010; 56(3):273–281.
7. M. Eddleston; S. Rajapakse; Rajakanthan, S. Jayalath; L. Sjöström; W. Santharaj; et al.). "Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial". Lancet, 2000; 355:967–972.
8. Kannan R. "Koels feeding on the yellow oleander.".Blackbuck, 1991; 7(2): 48.
9. Krishnan M. "Koels (Eudynamisscolopaceus) eating the poisonous fruit of the Yellow Oleander.” J. Bombay Nat. Hist. Soc, 1952; 50(4):943–945.
10. Raj,PJSanjeeva . "Additions to the list of birds eating the fruit of Yellow Oleander (Thevetia neriifolia).” J. Bombay Nat. Hist. Soc, 1963; 60(2):457–458.
11. Raj, P J Sanjeeva . "Birds eating poisonous fruit of Yellow Oleander (Thevetia neriifolia)". J. Bombay Nat.Hist.Soc, 1959; 56 (3): 639.
12. Neelakantan,KK . "Common Grey Hornbill (Tockusbirostris) eating fruits of the Yellow Oleander (Thevetia neriifolia)". J. Bombay Nat. Hist. Soc, 1953; 51(3):738.
13. Rajasingh,Simon G; Rajasingh,Irene V . "Birds and mammals eating the fruits of Yellow Oleander (Thevetia peruviana)". J. Bombay Nat. Hist. Soc, 1970; 67(3): 572–573.
14. Gupta R, Kachhawa JB, Gupta RS, Sharma AK, Sharma MC, Dobhal MP . "Phytochemical evaluation and antispermatogenic activity of Thevetia peruviana methanol extract in male albino rats". Hum Fertil (Camb), 2011; 14(1):53–59. Doi:10.3109/14647273.2010.542230.
15. Kareru P.G.; Keriko J.M.; Kenji G.M.; Gachanja A.N. "Anti-termite and antimicrobial properties of paint made fromThevetia peruviana (Pers.) Schum. Oil extract". African Journal of Pharmacy and Pharmacology, 2010; 4(2):87–89.
16. Islam Mazhar-Ul, Iqbal A, Usmanghani K, Shahab-Ud-Din, Ahmed A, Pakistan Journal of Pharmacology, 2001, 1-9.
17. Gehlot NK, Sharma VN, Vyas DS, Indian Journal of Pharmacology, 1976; 8:92-949.
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How to Cite
Jitpure, R., Yadav, S., Kurmi, R., Dhaker, K., Bhowmick, M., & Rathi, J. (2017). PHARMACOGNOSTIAL EVALUATION AND PHYTOCHEMICAL SCREENING OF THEVETIA PERUVIANA. Journal of Drug Delivery and Therapeutics, 7(1), 60-64. https://doi.org/10.22270/jddt.v7i1.1378