COMPARISON OF ANALGESIC EFFICACY OF ANTIEPILEPTIC GABAPENTIN WITH CONVENTIONAL ANALGESIC DICLOFENAC IN RAT EXPERIMENTAL MODELS

  • Saurabh Kansal Department of pharmacology, Subharti medical college, Meerut
  • Priti Sinha Department of anatomy, Subharti medical college, Meerut, India
  • Ruchika Agarwal Department of physiology, Subharti medical college, Meerut, India
  • Vatsala Sharma Department of paediatrics, Subharti medical college, Meerut, India

Abstract

Some  Antiepileptic  drugs  have  been  shown  to  be  clinically  efficacious   in  treatment  of neuropathic  pain  and  are  being  used  by  clinician.  This  study  determined  the  analgesic  effect  of gabapentin  (A  novel  Anticonvulsant)  in  rats  in  different  types  of  acute  and  chronic  nociceptive test  like  Tail flick  and Formalin test   &  compared  its  potency  with  a conventional  non  opioid  analgesic  diclofenac.  Per oral administration of  gabapentin  produced  no  any  marked  effect  on  early phase  response  of  formalin  test  but  significantly  suppressed  the  late  phase  response.  In   tail  flick  test  gabapentin  produced  no  any  significant  analgesic  effect  while  diclofenac  produced   significant  reduction  of  pain  in tail  flick  test  as  well  as  in  both  phases  of  formalin  test.  Thus  we  have  observed  that  gabapentin   produced  antinociception  in  chronic  pain  as  second  phase  of  formalin  test  reflects  chronic  inflammatory  pain  while  diclofenac  produced  both  acute  and  chronic  type  of  antinociceptive  effect  as  it  significantly  suppressed  the  pain  in  both  tail  flick  and  formalin  test.

Key Words: Gabapentin , diclofenac, nociception, formalin test, tailflick test

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Author Biographies

Saurabh Kansal, Department of pharmacology, Subharti medical college, Meerut

Department of pharmacology, Subharti medical college, Meerut

Priti Sinha, Department of anatomy, Subharti medical college, Meerut, India

Department of anatomy, Subharti medical college, Meerut, India

Ruchika Agarwal, Department of physiology, Subharti medical college, Meerut, India

Department of physiology, Subharti medical college, Meerut, India

Vatsala Sharma, Department of paediatrics, Subharti medical college, Meerut, India

Department of paediatrics, Subharti medical college, Meerut, India

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Kansal, S., Sinha, P., Agarwal, R., & Sharma, V. (2017). COMPARISON OF ANALGESIC EFFICACY OF ANTIEPILEPTIC GABAPENTIN WITH CONVENTIONAL ANALGESIC DICLOFENAC IN RAT EXPERIMENTAL MODELS. Journal of Drug Delivery and Therapeutics, 7(1), 44-48. https://doi.org/10.22270/jddt.v7i1.1370