COMPARISON OF ANALGESIC EFFICACY OF ANTIEPILEPTIC GABAPENTIN WITH CONVENTIONAL ANALGESIC DICLOFENAC IN RAT EXPERIMENTAL MODELS
SomeÂ AntiepilepticÂ drugsÂ haveÂ beenÂ shownÂ toÂ beÂ clinicallyÂ efficaciousÂ Â inÂ treatmentÂ of neuropathicÂ painÂ andÂ areÂ beingÂ usedÂ byÂ clinician.Â ThisÂ studyÂ determinedÂ theÂ analgesicÂ effectÂ of gabapentinÂ (AÂ novelÂ Anticonvulsant)Â inÂ ratsÂ inÂ differentÂ typesÂ ofÂ acuteÂ andÂ chronicÂ nociceptive testÂ likeÂ Tail flickÂ and Formalin testÂ Â &Â comparedÂ itsÂ potencyÂ withÂ a conventionalÂ nonÂ opioidÂ analgesicÂ diclofenac.Â Per oral administration ofÂ gabapentinÂ producedÂ noÂ anyÂ markedÂ effectÂ onÂ early phaseÂ responseÂ ofÂ formalinÂ testÂ butÂ significantlyÂ suppressedÂ theÂ lateÂ phaseÂ response.Â InÂ Â tailÂ flickÂ testÂ gabapentinÂ producedÂ noÂ anyÂ significantÂ analgesicÂ effectÂ whileÂ diclofenacÂ producedÂ Â significantÂ reductionÂ ofÂ painÂ in tailÂ flickÂ testÂ asÂ wellÂ asÂ inÂ bothÂ phasesÂ ofÂ formalinÂ test.Â ThusÂ weÂ haveÂ observedÂ thatÂ gabapentinÂ Â producedÂ antinociceptionÂ inÂ chronicÂ painÂ asÂ secondÂ phaseÂ ofÂ formalinÂ testÂ reflectsÂ chronicÂ inflammatoryÂ painÂ whileÂ diclofenacÂ producedÂ bothÂ acuteÂ andÂ chronicÂ typeÂ ofÂ antinociceptiveÂ effectÂ asÂ itÂ significantlyÂ suppressedÂ theÂ painÂ inÂ bothÂ tailÂ flickÂ andÂ formalinÂ test.Key Words: Gabapentin , diclofenac, nociception, formalin test, tailflick test
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