COMPARISON OF ANALGESIC EFFICACY OF ANTIEPILEPTIC GABAPENTIN WITH CONVENTIONAL ANALGESIC DICLOFENAC IN RAT EXPERIMENTAL MODELS
SomeÂ AntiepilepticÂ drugsÂ haveÂ beenÂ shownÂ toÂ beÂ clinicallyÂ efficaciousÂ Â inÂ treatmentÂ of neuropathicÂ painÂ andÂ areÂ beingÂ usedÂ byÂ clinician.Â ThisÂ studyÂ determinedÂ theÂ analgesicÂ effectÂ of gabapentinÂ (AÂ novelÂ Anticonvulsant)Â inÂ ratsÂ inÂ differentÂ typesÂ ofÂ acuteÂ andÂ chronicÂ nociceptive testÂ likeÂ Tail flickÂ and Formalin testÂ Â &Â comparedÂ itsÂ potencyÂ withÂ a conventionalÂ nonÂ opioidÂ analgesicÂ diclofenac.Â Per oral administration ofÂ gabapentinÂ producedÂ noÂ anyÂ markedÂ effectÂ onÂ early phaseÂ responseÂ ofÂ formalinÂ testÂ butÂ significantlyÂ suppressedÂ theÂ lateÂ phaseÂ response.Â InÂ Â tailÂ flickÂ testÂ gabapentinÂ producedÂ noÂ anyÂ significantÂ analgesicÂ effectÂ whileÂ diclofenacÂ producedÂ Â significantÂ reductionÂ ofÂ painÂ in tailÂ flickÂ testÂ asÂ wellÂ asÂ inÂ bothÂ phasesÂ ofÂ formalinÂ test.Â ThusÂ weÂ haveÂ observedÂ thatÂ gabapentinÂ Â producedÂ antinociceptionÂ inÂ chronicÂ painÂ asÂ secondÂ phaseÂ ofÂ formalinÂ testÂ reflectsÂ chronicÂ inflammatoryÂ painÂ whileÂ diclofenacÂ producedÂ bothÂ acuteÂ andÂ chronicÂ typeÂ ofÂ antinociceptiveÂ effectÂ asÂ itÂ significantlyÂ suppressedÂ theÂ painÂ inÂ bothÂ tailÂ flickÂ andÂ formalinÂ test.Key Words: Gabapentin , diclofenac, nociception, formalin test, tailflick test
2. Pain Free: Modern Drugs and Neuropathic Pain. J Korean Med Science 2002; 22: 360-7.
3. Maizes M, Mccarberg B. Antidepressant and antiepileptic drugs for chronic noncancer pain. Am Fam Physician 2005; 71: 483-90.
4. Assi D, Azim A, Rahman A, Mahran S. Analgesic effects of tramadol-diclofenac combination and their interaction with sycostimulant drugs in mice and rats. Eur J Pharmacol 1996;312:132-8.
5. Carrie K, Jones SC. Efficacy of duloxitine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. J Pharmacol Exp Ther 2005; 313: 726-32.
6. Pandi PV, Nagappa AN. Effect of acute and chronic treatment of losartan potassium on tailflick response in mice. Ind J Pharmacol 2006; 38: 281-2.
7. Vogel HG, Vogel WGH, editors, Drug discovery and evaluation-pharmacological assays. 2nd ed. New York: Verlog Springer publication;1996.
8. Bjorkman R, Hedner J, Hedner T, Henning M. Central naloxone â€“reversible antinociception by diclofenac in the rat. Bio Med Life Sci 1990; 342: 171-6.
9. Pinardi G, Sierralta F, Miranda HF. Adrenergic mechanisms in antinociceptive effects of nonsteroidal anti-inflammatory drugs in acute thermal nociception in mice. Inflammation Res 2002; 51: 219-22.
10. Sukriti, Hota D, Pandhi P. Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. Exp Clin Pharmacol 2004; 26: 253.
11. Hernandez GC, Soto VG, Ortiz MI. Pinacidil increases diclofenac antinociception in the formalin test. Proc West Pharmacol Soc 2005; 48: 55-8.
12. Lorem LC, Mitchell D, Skosana Musi, Fick LG. Tramadol is more effective than morphine and amitriptyline against ischaemic pain but not thermal pain in rats. Pharmacol Res 2007; 56: 80-5.
13. Shamsi MM, Mobasher M, Sepehri G, Haghdoost AA, Babaie M. Intraventricular gabapentin is antinociceptive and enhances systemic morphine antinociception in rat tail flick test.DARU 2007; 15:212-7.
14. Yoon MH, Choi J, Kwak SH. Characteristic of interaction between intratheca gabapentin and either clonidine or neostigmine in the formalin test. Anesth Analg 2004; 98: 1374-9.
15. Carlton SM, Zhou S. Attenuation of formalin induced nociceptive behaviors following local peripheral injection of gabapentin. Pain 1998; 76: 201-7.
16. Heughan CE, Sawynok J. The interaction between gabapentin and amitryptyline in the rat formalin test after systemic administration. Anesth Analg 2002; 94: 975-80.
17. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L. Gabapentin (neurontin) and s-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 1997;121:1513-22.
18. Urban MO, Ren K, Park KT, Campbell B, Anker N, Stearns B, et al. Comparison of the antinociceptive profiles of gabapentin and 3 methyl gabapentin in rat models of acute and persistent pain: Implications for mechanism of action. J Pharmacol Exp Ther 2005; 313: 1209-16.
19. Dickenson D, Sullivan AF. Peripheral origins and central modulation of subcutaneous formalin induced activity of rat dorsal horn neurons. Neurosci Lett 1987; 83: 207-11.
20. Field MJ, Hughes J, Singh L. Further evidence for the role of the alpha2 delta subunit of voltage dependent calcium channels in models of neuropathic pain. Br J Pharmacol 2000; 13: 282-6
21. Cheng JK, Lai YJ, Chen CC, Cheng CR, Chiou LC. Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in arat model of postoperative pain. Anesthesiology 2003; 98: 1472-9.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).