NEW SLANT ON HYPERLIPIDEMIA: PREVENTION BY VITAMIN B-3 AND COMMON FRUIT ZIZIPHUS JUJUBA

  • Khalid Niaz Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)
  • Ajaz Fatima Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)
  • M. Ashraf Memon Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)
  • Shahina Hakro Dept of Pharmacology, ISLAMABAD MEDICAL AND DENTAL COLLEGE, ISLAMABAD-PAKISTAN (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)
  • Shah Murad Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Abstract

Coronary artery disease (CAD) is complication of primary or secondary hyperlipidemia. Etiological factors for hyperlipidemia include inherited genetic defects in low density lipoproteins (LDLs), persons accustomed to sit for prolong time, cigarette smoking, diabetes mellitus, and hypertension. This research work’s aim was to compare hypolipidemic features of an allopathic agent vitamin B-3 and another medicinal plant Z. Jujuba. Study was conducted from January 2016 to June 2016 at Jinnah Hospital Lahore, Pakistan. 60 male and female hyperlipidemic patients age range from 20 to 70 years were selected from the hospital. Written and explained consent was taken from all patients. They were divided in two groups. Group-I was advised to take two grams vitamin B-3 in divided doses for the period of two months. Group-II was advised to take 500 grams of fruit Z. Jujuba daily for 60 days per their convenience. Their initial LDL and HDL cholesterol was determined by Friedwald’s formula. After 60 days therapy, their post treatment lipid profile was measured and mean values with ± SD were analyzed biostatistically by using SPSS version 2; 2010. Group-I which was on vitamin B-3 their LDL cholesterol decreased significantly and HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was decreased significantly but HDL increase was not significant with p-value of >0.05. It was concluded from the research study that vitamin B-3 is potent hypolipidemic agent as compared to medicinal plant Z. Jujuba.

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Author Biographies

Khalid Niaz, Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Ajaz Fatima, Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

M. Ashraf Memon, Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Shahina Hakro, Dept of Pharmacology, ISLAMABAD MEDICAL AND DENTAL COLLEGE, ISLAMABAD-PAKISTAN (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)
Dept of Pharmacology, ISLAMABAD MEDICAL AND DENTAL COLLEGE, ISLAMABAD-PAKISTAN (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)
Shah Murad, Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

Islamabad Medical and Dental College, Islamabad-Pakistan (Affiliated with Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad)

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1.
Niaz K, Fatima A, Memon MA, Hakro S, Murad S. NEW SLANT ON HYPERLIPIDEMIA: PREVENTION BY VITAMIN B-3 AND COMMON FRUIT ZIZIPHUS JUJUBA. JDDT [Internet]. 14Nov.2016 [cited 28Oct.2020];6(6):22-4. Available from: http://jddtonline.info/index.php/jddt/article/view/1342