COLORIMETRIC METHODS FOR THE ESTIMATION OF TOPIRAMATE IN TABLETS

  • P G Sunitha Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, TamilNadu, India.
  • N Deattu Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, TamilNadu, India.
  • R Dhanalakshmi Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India
  • A Gangatharan Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India
  • Bharathi A Kavi Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India
  • G Murali Shankar Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India
  • M Sathya Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Abstract

Two simple sensitive and precise colorimetric methods A and B were developed for the estimation of topiramate in bulk drug as well as in pharmaceutical dosage form. Methods A is based on the formation of yellow coloured chromogen by condensation reaction of topiramate with Ehrlich’s reagent ( p - dimethyl amino benzaldehyde ) which has absorption maximum at 547nm. Method B is based on the formation of an orange coloured complex by oxidation reaction of topiramate with 2,2’- bipyridyl in the presence of ferric chloride which has absorption maximum at 519nm. The proposed methods are statistically validated and found to be useful for the routine determination of topiramate in tablets.

Keywords: Topiramate, Colorimetry, Tablets, Validation

Downloads

Download data is not yet available.

Author Biographies

P G Sunitha, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, TamilNadu, India.

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, TamilNadu, India.

N Deattu, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, TamilNadu, India.

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, TamilNadu, India.

R Dhanalakshmi, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

A Gangatharan, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Bharathi A Kavi, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

G Murali Shankar, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

M Sathya, Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India

References

1. The Merck Index, An encyclopedia of chemical drugs & biologicals. ed13, Merck research laboratories division of MERCK & CO., INC; 2001:P. 1703.
2. Martindale, the complete drug reference. ed 37, Vol. A. London, Pharmaceutical press; 2011: P 551.
3. Tripathy KD. Essentials of medical pharmacology. ed 6, Jaypee brothers Medical Publishers; 2010:P172, 402,404.
4. Shanbhag T, Shenoy S. Pharmacology prepared manual for under graduates. ed 2, Reed Elsevier India Private limited; 2015:P191, 196.
5. Indian Pharmacopoeia 2010, Vol lll, ed 6, Ghaziabad, Indian pharmacopoeia commission. P2242.
6. Carl E, Wolf C. Richard Crooks, Alphonse Poklis, Rapid gas chromatographic procedure for the determination of topiramate in serum, J of anal toxicol, 2000; 24:661.
7. Christensenj G, Hojskov CS, Poulsen JH, Ther. Drug monitoring, 2002; 24(5):658-664.
8. Kashyap R, Subramanyam EVS, Sharbaraya AR, A review on topiramate and available analytical method, Int J. Pharm and Chem Sci, 2012; 2:880-881.
Statistics
122 Views | 163 Downloads
How to Cite
1.
Sunitha P, Deattu N, Dhanalakshmi R, Gangatharan A, Kavi B, Murali Shankar G, Sathya M. COLORIMETRIC METHODS FOR THE ESTIMATION OF TOPIRAMATE IN TABLETS. JDDT [Internet]. 12Sep.2016 [cited 26Sep.2020];6(5):11-3. Available from: http://jddtonline.info/index.php/jddt/article/view/1308