COLORIMETRIC METHODS FOR THE ESTIMATION OF TOPIRAMATE IN TABLETS
Two simple sensitive and precise colorimetric methods A and B were developed for the estimation of topiramate in bulk drug as well as in pharmaceutical dosage form. Methods A is based on the formation of yellow coloured chromogen by condensation reaction of topiramate with Ehrlichâ€™s reagent ( p - dimethyl amino benzaldehyde ) which has absorption maximum at 547nm. Method B is based on the formation of an orange coloured complex by oxidation reaction of topiramate with 2,2â€™- bipyridyl in the presence of ferric chloride which has absorption maximum at 519nm. The proposed methods are statistically validated and found to be useful for the routine determination of topiramate in tablets.
Keywords: Topiramate, Colorimetry, Tablets, Validation
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