SINGLE BLIND PLACEBO-BASED STUDY ON PREVENTION OF CORONARY ARTERY DISEASE (CAD) BY INJEER AND ISPAGHULA
Introduction: Injeer and Ispaghula are frequently/successfully used for treatment of both primary and secondary Hyperlipidemia. Major cardiac diseases are directly or indirectly linked with high levels of lipids in systemic circulation.Â Various medicinal herbs can normalize lipid profile of patients suffering from primary or secondary hyperlipidemia with or without metabolic syndrome.
Place of research work: It was conducted at Jinnah hospital Lahore-Pakistan from January to May 2016. One hundred hyperlipidemic patients were enrolled for the research work.
Type of research study: This research work was single blind placebo-controlled.
Criteria for inclusion and exclusion: Primary or secondary hyperlipidemic patients of both gender, age range from 20 to 65 years were included in research. Patients suffering from any major organ disease like renal, hepatic, pulmonary diseases and already on drugs for major cardiac disease were excluded from the study.
Grouping of participants: Patients were divided in four groups, 25 patients in each group. Group-I was on Injeer, Group-II was on Ispaghula, Group-III was on combination of these two herbal medicines, and Group-IV was considered as control group.
Determination of TC, TG, LDL-C and HDL-C: Base line lipid profile was measured in Pathology Laboratory of JINNAH HOSPITAL.
Result compilation and biostatistical analysis: After three months therapy, their lipid profile was determined and mean values with Â±SEM were compared before and after treatment. When analyzed statistically and compared with placebo effects, all patientsâ€™ LDL-cholesterol was reduced significantly. HDL-cholesterol was increased in all groups of patient.
Conclusion: Final conclusion of research work was that at specific concentration and period of ingestion of herbs like psyllium husk, and figs can reduce risk of hyperlipidemia leading to development of cardiac diseases, especially coronary artery disease.
2. Heiss G, Tamir I, Davis CE, Tyroler HA, Rifkind BM, Schonfeld G, Jacobs DR Jr, Frantz ID Jr. Lipoprotein cholesterol distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. Circulation. 2012; 61:302-15.
3. Kostapanos MS, Liamis GL, Milionis HJ, Elisaf MS. Do statins beneficially or adversely affect glucose homeostasis? Curr Vasc Pharmacol. 2010; 8:612-631.
4. de Amorin A, Borba HR, Carauta JP, et al. Anthelmintic activity of the latex of Ficus species. J Ethnopharmacol 2009; 64(3):255-8.
5. Sanchez-Moreno C: Methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Sci Technol Int 2012; 8:121-37.
6. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease: the Framingham Study. Am J Med. 2014; 62:707-14.
7. Jian-Ke An, Wen-Bo Wang, Ai-Qin Wang. Preparation and uses of Psyllium husk. Starch-Starke 2010; 62(10):501-7.
8. Rice-Evans CA, Miller NJ, Paganga G: Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 2011; 20:933-56.
9. Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P, Van Horn L, Tracy RP, Lloyd-Jones DM. Lifetime risks of cardiovascular disease. N Engl J Med. 2012; 366(4):321-9.
10. Hong Wang, Gu Chen, Dandan Ren, Shang-Tian Yang. Hypolipidemic Activity of Ispaghula. Phytotherapy Research 2014; 28(2):268-73.
11. Canal JR, Torres MD, Romero A, Perez C. A chloroform extract obtained from a decoction of Ficus carica leaves improves the cholesterolaemic status of rats. Acta Physiol Hung 2010; 87(1):71-6.
12. Fredrickson DS, Levy RI, Lees RS. Fat transport in lipoproteins-an integrated approach to mechanisms and disorders. N Engl J Med. 2013; 276:94-103.
13. Brensike JF, Levy RI, Kelsey SF, Passamani ER, Richardson JM, Loh IK, Stone NJ, Aldrich RF, Battaglini JW, Moriarty DJ, et al. Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: results of the NHLBI Type II coronary intervention study. Circulation. 2014; 69:313-24.
14. Wei Liu, Boce Zhang, Qin Wang, Zhouhong Xie, Wenbing Yao, Xiangdong Gaoand Liangli (Lucy) Yu. Effects of Sulfation on the Physicochemical and Functional Properties of Psyllium. Journal of Agricultural and Food Chemistry 2010; 58(1):172-79.
15. Lyme WE, Sen YS, Paralu YT. Hypoglycemic action of an oral fig-leaf in type-II diabetic patients. Diabetes Research and Clinical Practice 2008; 39(1):1200-1211.
16. Sze-Yuan Chou, Po-Jung Chien and Chi-Fai Chau. Effects of Psyllium Hyrophilic Mucilloid in hyperlipidemia. Journal of Agricultural and Food Chemistry 2008; 56(22):1094-98.
17. Zeggwagh N.A., Moufid A., Khaldi A., Michel J.B., Eddouks M. Cardiovascular effects of Ficus Carica. Circulation 2010; 6(8):343-6.
18. Perez C, Domingues E, Torres MD. Hypolipidemic activity of an aqueous extract from Fig tree leaves. Pharmaceutical Biology 2009; 38(3):181-6.
19. Deb T, Ghosh A, Bhadra B, Drug utilization study in Pregnancy induced hypertension in a tertiary care teaching hospital, Journal of Drug Delivery and Therapeutics, 2014; 4(2):169-172
20. Stadtman ER. Herbal medicines used as hypolipidemic agents. Free Radical Biol. Med. 2012; 9:315-25.
21. Lissi EA, Salim-Hanna Pascual C, Del-Castillo M. Herbs and their biochemical characteristics. Free Radical Biol. Med. 20014; 18:153-58.
22. Hossain P, Kawar B, El Nahas M. Psyllium husk for lipids lowering effect. N Engl J Med 2014;356:213-5.
23. Verma SK, Jain V, Singh DP. Effect of husk, figs on blood lipids, fibrinolysis and total antioxidant status in patients with ischemic heart disease. APJTD 2012; 2 Suppl 2: 739-43.
24. Drewnowski A, Popkin BM., Walker EL, Tastor V. The nutrition transition: ne-w trends in the global diet. Nutr Rev 2011; 55:31-43.
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