SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINOLINE BASED IMIDAZOLES

  • Sunil Vodela Department of Chemistry, Talla Padmavathi College of Engineering, Warangal 506 009, Telangana, India
  • Venu Chakravarthula Department of Chemistry, Osmania University, Hyderabad, 500 037506009, Telangana, India

Abstract

A simple and convenient method has been developed for the synthesis of title compounds, 1-methyl-2-phenyl-1H-imidazo[4,5-f]-quinoline and derivatives (5a-f) in reasonable yields. The commercially available 6-nitro-quinoline-5-amine (1) is used as raw material and it is reduced conveniently using SnCl2 to give the initial intermediate, quinoline-5,6-diamine (2) in good yield. Compound 2 on consecutive steps when treated on condensation followed by cyclization generated the rest of intermediates, N6-benzylidene-quinoline-5,6-diamines (3a-f) and 2-phenyl-1H-imidazo[4,5-f]-quinolines (4a-f) respectively. The chemical structures of all newly prepared compounds were elucidated using infrared, 1H NMR and mass spectral studies as well as elemental analysis. The output of this synthetic method has been provided a series of successful biologically important structures.

Keywords: Quinoline, imidazole, antimicrobial activity

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Author Biographies

Sunil Vodela, Department of Chemistry, Talla Padmavathi College of Engineering, Warangal 506 009, Telangana, India
Department of Chemistry, Talla Padmavathi College of Engineering, Warangal 506 009, Telangana, India
Venu Chakravarthula, Department of Chemistry, Osmania University, Hyderabad, 500 037506009, Telangana, India
Department of Chemistry, Osmania University, Hyderabad, 500 037506009, Telangana, India

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How to Cite
Vodela, S., & Chakravarthula, V. (2016). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINOLINE BASED IMIDAZOLES. Journal of Drug Delivery and Therapeutics, 6(5), 6-10. https://doi.org/10.22270/jddt.v6i5.1278