SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINOLINE BASED IMIDAZOLES
A simple and convenient method has been developed for the synthesis of title compounds, 1-methyl-2-phenyl-1H-imidazo[4,5-f]-quinoline and derivatives (5a-f) in reasonable yields. The commercially available 6-nitro-quinoline-5-amine (1) is used as raw material and it is reduced conveniently using SnCl2 to give the initial intermediate, quinoline-5,6-diamine (2) in good yield. Compound 2 on consecutive steps when treated on condensation followed by cyclization generated the rest of intermediates, N6-benzylidene-quinoline-5,6-diamines (3a-f) and 2-phenyl-1H-imidazo[4,5-f]-quinolines (4a-f) respectively. The chemical structures of all newly prepared compounds were elucidated using infrared, 1H NMR and mass spectral studies as well as elemental analysis. The output of this synthetic method has been provided a series of successful biologically important structures.
Keywords: Quinoline, imidazole, antimicrobial activity
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