VARIOUS TECHNIQUES OF BIOAVAILABILITY ENHANCEMENT: A REVIEW

  • Azhar Danish Khan Ram-Eesh Institute of Vocational and Technical Education Greater Noida
  • Lubhan Singh Ram-Eesh Institute of Vocational and Technical Education Greater Noida

Abstract

Bioavailability is defined as the rate and extent (amount) of absorption of unchanged drug from its dosage form. It is one of the important parameters which are required to achieve optimal concentration of drug in systemic circulation to show a pharmacological response. A drug which has poor bioavailability shows poor aqueous solubility, slow dissolution rate, poor stability of dissolved drug at physiological pH, poor permeation through biological membrane, extensive first pass metabolism. Drugs which are poorly water soluble require high doses to obtain therapeutic plasma concentrations after oral administration of drugs. Low aqueous solubility is the major problem encountered with formulation development of new drugs. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. This review deals with various techniques used for the improvement of the Bioavailability of drugs. The various techniques used are size reduction, solubilising excipients, colloidal drug delivery systems, pH adjustment, solid dispersion, complexation, coâ€solvency, micellar solubilisation, hydrotropy etc. The article describes about various techniques which can be utilized to enhance bioavailability of drugs enhancement for their effective absorption in the body

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Author Biographies

Azhar Danish Khan, Ram-Eesh Institute of Vocational and Technical Education Greater Noida

Ram-Eesh Institute of Vocational and Technical Education Greater Noida

 

Lubhan Singh, Ram-Eesh Institute of Vocational and Technical Education Greater Noida

Ram-Eesh Institute of Vocational and Technical Education Greater Noida

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Khan AD, Singh L. VARIOUS TECHNIQUES OF BIOAVAILABILITY ENHANCEMENT: A REVIEW. JDDT [Internet]. 15May2016 [cited 29Mar.2024];6(3):34-1. Available from: https://jddtonline.info/index.php/jddt/article/view/1228