DENDRIMERS IN DRUG DELIVERY, DIAGNOSIS AND THERAPY: BASICS AND POTENTIAL APPLICATIONS

  • Sunil Kumar Prajapati Dept. of Pharmacy, Bundelkhand University, Jhansi, India
  • Sheo Datta Maurya Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India
  • Manas Kumar Das Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India
  • Vijay Kumar Tilak Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India
  • Krishna Kumar Verma Ram-Eish Institute of Pharmacy, Greater noida, India
  • Ram C Dhakar Jhalawar Medical College & Hospital, Jhalawar, India

Abstract

This review gives concise information about the dendrimers, properties, synthesis and application in drug delivery, diagnosis and therapy. Due to their unique architecture these have improved physical and chemical properties. They show high solubility, miscibility and reactivity due to their terminal groups. Dendrimers have well defined size, shape, molecular weight and monodispersity. These properties make the dendrimers a suitable carrier in drug delivery application. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs. Their compatibility with DNA, heparin and polyanions make them more versatile. Dendrimers, also referred as modern day polymers, they offer much more good properties than the conventional polymers. Due to their multivalent and mono disperse character dendrimers have stimulated wide interest in the field of chemistry biology, especially in applications like drug delivery, gene therapy and chemotherapy. Self assembly produces a faster means of generating nanoscopic functional and structural systems. But their actual utility in drug delivery can be assessed only after deep understanding of factors affecting their properties and their behavior in vivo.

Key words: Dendrimers, PAMAM, monodispersity, Divergent-Convergent synthesis, carrier for drug delivery

 

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Author Biographies

Sunil Kumar Prajapati, Dept. of Pharmacy, Bundelkhand University, Jhansi, India

Dept. of Pharmacy, Bundelkhand University, Jhansi, India

Sheo Datta Maurya, Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India

Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India

Manas Kumar Das, Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India

Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India

 

Vijay Kumar Tilak, Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India

Dept. of Pharmacy, IEC Group of Institution, Greater Noida, India

Krishna Kumar Verma, Ram-Eish Institute of Pharmacy, Greater noida, India

Ram-Eish Institute of Pharmacy, Greater noida, India

Ram C Dhakar, Jhalawar Medical College & Hospital, Jhalawar, India

Jhalawar Medical College & Hospital, Jhalawar, India

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Prajapati S, Maurya S, Das M, Tilak V, Verma K, Dhakar R. DENDRIMERS IN DRUG DELIVERY, DIAGNOSIS AND THERAPY: BASICS AND POTENTIAL APPLICATIONS. JDDT [Internet]. 17Jan.2016 [cited 28Feb.2020];6(1):67-2. Available from: http://jddtonline.info/index.php/jddt/article/view/1190

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