PRELIMINARY PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF AROGYAVARDHINI COMPOUND- AN EMERGING FORMULATED MEDICINE FOR METABOLIC SYNDROME

  • Bharatkumar Chhaganbhai Padhar Ph.D Scholar Kayahikitsa Department I.P.G.T and R.A Gujarat Ayurved University Jamnagar 361008
  • Alankruta R Dave Associate Prof. & I/C Head of Department of Kayachikitsa, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India
  • C R Harisha Head of Pharmacognosy laboratory, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India
  • V J Shukla Head of Pharmaceutical laboratory, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India
DOI https://doi.org/10.22270/jddt.v6i1.1185

Abstract

Context: Arogyavardhini Compound is an emerging formulated herbo-mineral formulation for treatment of metabolic syndrome. Metabolic syndrome is group of risk factors like, increased waist circumference, insulin resistance, increased triglycerides, decreased high density lipoproteins and hypertension for coronary artery diseases and type 2 diabetes mellitus. Arogyavardhini compound consist equal quantity of Arogyavardhini Rasa and single bulb garlic powder. Arigyavardhini Rasa having proven anti dyslipidemiac and weight reducing effect and Garlic having antidiabetic, antidyslipidemic, antihypertensive effect, the combination called Arogyavardhini Compound has been formulated for management of metabolic syndrome. Aim: Authentication of raw drug of Arogyavardhini Compound and phytochemical evaluation of finished product. Materials and methods: Arogyavardhini Compound was evaluated on the basis of powder microscopy and analytical parameters like pH, Ash value, acid insoluble ash, water soluble extract, methanol extract and high performance thin layer chromatography. Results: Powder microscopy revealed the presence of Annular vessels of Musta, Starch grains of Vacha, Stone cells of Pippali, Stone cells of Chitraka, Oleoresins of Shunthi, etc. Physicochemical parameters such as total Ash value (15.91%), water soluble extract (13.5%), methanol soluble extract (17.2%) were assessed in preliminary physicochemical scanning. HPTLC revealed maximum 09 spots in short wave UV 254 nm. and 07 spots were obtained in long wave UV 366 nm. Conclusion: Pharmacognostical study revealed genuinity of raw drugs. Physico-chemical and HPTLC studies inferred that the formulation meets the minimum quality standards as reported in the API at a preliminary level. The inference from this study may be used as reference standard in the further quality control researches.

KEY WORDS: Arogyavardhini Compound, HPTLC,Pharmacognosy, Physicochemical analysis.

Keywords: Therapeutics

Downloads

Download data is not yet available.

Author Biographies

Bharatkumar Chhaganbhai Padhar, Ph.D Scholar Kayahikitsa Department I.P.G.T and R.A Gujarat Ayurved University Jamnagar 361008

Ph.D ScholarKayahikitsa DepartmentI.P.G.T and R.AGujarat Ayurved UniversityJamnagar 361008

Alankruta R Dave, Associate Prof. & I/C Head of Department of Kayachikitsa, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India

Associate Prof. & I/C Head of Department of Kayachikitsa, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India

C R Harisha, Head of Pharmacognosy laboratory, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India
Head of Pharmacognosy laboratory, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India
V J Shukla, Head of Pharmaceutical laboratory, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India

Head of Pharmaceutical laboratory, I.P.G.T & R.A, Gujarat Ayurved University Jamnagar, India

References

1. In: Ayurvedic Formulary of India, part-1A, 20/4. 2nd ed. New Delhi: Dept. of ISM and H, Ministry of Health and Family Welfare, Govt. of India; 2003:58.

2. Agnivesha, Charaka, Dridhabala, Charaka Samhita, Sutra Sthana, KiyantaShirashiyaha Adhyaya, 17/8, edited by Yadavaji Trikamji Acharya, 1 st ed. Chaukhambha Surbharathi Prakashana, Varanasi, 2011;198.

3. Ras-tarangini, Taranga 06 / 112, “Rasvigyana commentary” by Kashinath Shastri, 11th ed. Delhi: Motilal Banarasidas publication; 2009. p. 126.

4. Ras-tarangini, Taranga 17 / 46, “Rasvigyana commentary” by Kashinath Shastri, 11th ed. Delhi: Motilal Banarasidas publication; 2009. p. 420.

5. Ras-tarangini, Taranga 10 / 72, “Rasvigyana commentary” by Kashinath Shastri, 11th ed. Delhi: Motilal Banarasidas publication; 2009. p. 234.

6. Ras-tarangini, Taranga 20 / 83, “Rasvigyana commentary” by Kashinath Shastri, 11th ed. Delhi: Motilal Banarasidas publication; 2009. p. 507.

7. Ras-tarangini, Taranga 22/ 25, “Rasvigyana commentary” by Kashinath Shastri, 11th ed. Delhi: Motilal Banarasidas publication; 2009. p. 586.

8. Bhavamishra, Bhavaprakasha Nighantu, Haritakyadi varga 3 / 43, commentary by Pandit Brahma Shankar Mishra, 1st ed. Varanasi: Chaukhambha Bharati Akademy; 2010. p. 12.

9. Bhavamishra, Bhavaprakasha Nighantu, Haritakyadi varga 46 / 152, commentary by Pandit Brahma Shankar Mishra, 1st ed. Varanasi: Chaukhambha Bharati Akademy; 2010. p. 67.

10. Bhavamishra, Bhavaprakasha Nighantu, Haritakyadi varga 77/ 221-223, commentary by Pandit Brahma Shankar Mishra, 1st ed. Varanasi: Chaukhambha Bharati Akademy; 2010. p. 126.

11. Lee HS, Yoo CB, Ku SK. Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse. Fitoterapia. 2006;77:579–84.

12. Maruthappan V, Shree KS. Hypolipidemic activity of haritaki (Terminalia chebula) in atherogenic diet induced hyperlipidemic rats. J Adv Pharm Technol Res. 2010;1:229–35.

13. Saravanan S, Srikumar R, Manikandan S, Jeya Parthasarathy N, Sheela Devi R. Hypolipidemic effect of triphala in experimentally induced hypercholesteremic rats. Yakugaku Zasshi. 2007;127:385–8.

14. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of Amla fruit (Emblica officinalis Gaertn) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62:609–16.

15. Nohr LA, Rasmussen LB, Straand J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther Med. 2009;17:16–22.

16. Peyman M, Surush M, Milad M, Shahin A, Shadi S. Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds. Iran J Basic Med Sci. 2013 Oct; 16(10): 1031–1048.

17. http://en.wikipedia.org/wiki/Metabolic_syndrome#cite_note-1

18. Anonymous. Guidelines on Quality of Herbal Medicinal Products/Traditional Medicinal Products, EMEA/CVMP/814OO Review, London: European Agency for the Evaluation of Medicinal Products (EMEA) publications; 2005.

19. Anonymous. The Use of Essential Drugs, Eighth report of the WHO Expert committee. Geneva: World Health Organization publications; 1990.

20. Wickramasinghe M, Bandaranayake. Quality control, Screening, toxicity, and regulation of herbal drugs. In: Ahmad I, Aqil F, Owais M, editors. Modern phytomedicine, turning medicinal plants into drugs, Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA; 2006. p. 27-57

21. Mukherjee PK, Wahile A. Integrated approaches towards drug development from Ayurveda and other Indian systems of medicine. J Ethnopharmacol 2006; 103:25-35.

22. Satheesh KP, Kumar KV, Menta L, Gopal Rao K, Elsheikh Musad MM, Koko Mohamed ME. Standardization of a Polyherbal Ayurveda Formulation Nishamalaki Churna Tablet. J Pharm Res 2011; 4:1483-7.

23. Wallis TE. Text Book of Pharmacognosy. 5 th ed. New Delhi: CBS Publishers; 1985. p. 571

24. Khandelwal KR. Practical Pharmacognosy techniques and experiments. 19th ed. Pune: Nirali Prakashan; 2008. p. 149-66.

25. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 42 nd ed. Pune: Nirali Prakashan; 2008. P.102.

26. Anonymous, The Ayurvedic Pharmacopoeia of India, Part 2, Vol. 1, 1 st ed. New Delhi: Department of AYUSH, Ministry of Health and Family welfare, Government of India; 2008. p.140.

27. Anonymous. Quality control methods for medicinal plant materials, Geneva: World Health Organization; 1998.

28. Anonymous, Parameters for qualitative assessment of Ayurveda and Siddha drugs, Part A, New Delhi: CCRAS; 2005. pp. 31.

29. Stahl E. A Laboratory hand book. Berlin: Springer-Verlag; 1969. P.102.

30. Gupta AK.introduction to pharmaceutics Vol.-1.3rd ed. New Delhi: CBS publishers and distribeuters; 1994.p.270.
P
Statistics
119 Views | 213 Downloads
How to Cite
1.
Padhar B, Dave A, Harisha C, Shukla V. PRELIMINARY PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF AROGYAVARDHINI COMPOUND- AN EMERGING FORMULATED MEDICINE FOR METABOLIC SYNDROME. JDDT [Internet]. 15Jan.2016 [cited 27Feb.2020];6(1):46-0. Available from: http://jddtonline.info/index.php/jddt/article/view/1185
Issue
Vol 6 No 1 (2016): Volume 6, Issue 1, Jan-Feb 2016
Section
Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).