DEVELOPMENT AND OPTIMIZATION OF CHRONOPHARMACEUTICAL DRUG DELIVERY SYSTEM FOR ASTHMA

  • Shilpa Praveen Chaudhari
  • Pallavi M Chaudhari Padmashree Dr.D.Y.Patil College of Pharmacy,Akurdi,Pune-44
  • Sandeep Narawane Marathwada Mitra Mandal's College of Pharmacy,Thergaon,Pune-33

Abstract

The present research was designed to increase bioavailability and solubility of Montulokast Sodium by formulating Chrono pharmaceutical delivery system. In the present study firstly immediate release core tablets were prepared by direct compression using Response Surface Methodology with different superdisintegrants, diluents and surfactants to release drug faster. In that formulation containing cross carmellose sodium and Poloxomer-188 with highly soluble lactose gave 95% release in 30 minutes with optimum pre & post compression characteristics. Chronopharmaceutical Drug delivery formulations were then prepared by press coating using polymers as Xanthan gum, Polyox, HPMC & Ethyl Cellulose alone and in combination. The results revealed that combinations of these polymers give better lag time rather than using a single polymer.Thus it can be concluded that combining hydrophilic and hydrophobic polymer can be done to achieve the respected lag time required for pulsatile release.

Keywords: , Montelukast Sodium, Chronopharmaceutical Drug Delivery System

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Author Biographies

Shilpa Praveen Chaudhari
Department of Pharmaceutics
Pallavi M Chaudhari, Padmashree Dr.D.Y.Patil College of Pharmacy,Akurdi,Pune-44
Department of Pharmaceutics

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How to Cite
Chaudhari, S., Chaudhari, P., & Narawane, S. (2016). DEVELOPMENT AND OPTIMIZATION OF CHRONOPHARMACEUTICAL DRUG DELIVERY SYSTEM FOR ASTHMA. Journal of Drug Delivery and Therapeutics, 6(1), 25-33. https://doi.org/10.22270/jddt.v6i1.1178