FORMULATION AND EVALUATION OF EFFERVECENT FLOATING TABLETS OF ANTIDIABETIC DRUG
The aim present investigation is Formulation and Evaluation of Effervescent Floating Tablets of antidiabetic drug. Gastric retention are such systems, which increase the gastric retention time of the dosage forms at the stomach and upper part of the small intestine and suitable for the drug having site-specific absorption from the above sites. The Metformin HCl an orally administered biguanide ofÂ BCS class-3 High solubility and low permeability, which is widely use in the management of and the type-II diabetes, is an oral anti- hyperglycemic agent, shows incomplete absorption from the gastrointestinal tract and from the gastrointestinal track and absolute bioavailability is 50-60%with relatively short plasma half-life of 1.5-4.5 hours. It was using different polymers studying of deferent factors affecting the floating behavior of the prepare tablets was of our goals and important target in this part. Gastro-retentive tablets of Metformin HCl were prepared by wet granulation method using HPMC K200M (Hydroxylpropyl methyl cellulose) micro crystalline cellulose PH 101, sodium bicarbonate, HPMC K100 (LV), Magnesium stearate, colloidal silicon dioxide. In this formulation HPMC K 200 M was using different concentration. The Gastro-retentive tablet of Metformin HCl was evaluation of compression blend Angle of repose, Bulk density, tapped density, Drug compressibility study, Drug release rate, floating lag time etc. Result of our present study suggests that gastro-retentive tablets of Metformin HCl can be successfully designed to develop sustained release drug delivery which can reduce dosing frequency.
Keywords: Effervescent system, gas generating system, gastro retentive drug delivery system, sustained drug release, Metformin hydrochloride
2. Dunn, C. J.; Peters D. H. Metformin. A review of its pharmacological properties and therapeutic use in non insulindependant diabetes mellitus. Drugs 1995, 49 (5), 721-749.
3. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv 2006; 3(2): 217- 33.
4. Iannucelli V, Coppi G, Bernabei MT, Camerorni R. Air compertment multiple-unit system for prolonged gastric residence. Part-I. Formulation study. Int J Pharm 1998; 174: 47-54.
5. The United States pharmacopoeia XX/National formulary XV. U.S. Pharmacopoeial convention, Rock-ville, MD, 1980; pg 958,990.
6. Lachman, L.; Lieberman, H.A.; Lachman, kaling, J.L. The theory and practice of industrial pharmacy, 3rded., Varghese Publishing House, Bombay, 1987; pg 296.
7. Lachman, L.; Lieberman, H.A.; Lachman, kaling, J.L. The theory and practice of industrial pharmacy, 3rd ed., Varghese Publishing House, Bombay, 1987; pg 297-98.
8. Indian pharmacopoeia, 5th ed., Published by the Indian pharmacopoeia commission,Ghaziabad, 2007; Vol. 1, pg 183.
9. The United States pharmacopoeia XX/National formulary XV. U.S. Pharmacopoeial convention, Rock-ville, MD, 1980; pg 958,990. Page 68
10. Srivastava, A. K.; Wadhwa, S.; Ridhurkar, D.; Mishra, B. Oral sustained delivery of atenolol from floating matrix tablets formulation and in-vitro evaluation. Drug Dev. Ind. Pharm., 2005; Vol. 31: pg 367â€“374.
11. Margret, C.; Bhavesh.; Venkateshwarlu, B.S.; Jayakar, B.; Bhowmik, D.; Sampath, K.P. Studies on formulations and evaluation of floating tablets containing anti-ulcer drugs, scholar research library, 2009; pg 102-114.
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